BCL11A and YME1L1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BCL11A	YME1L1
Description		BCL11 transcription factor A	YME1 like 1 ATPase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix SWI/SNF Complex Paraspeckles Postsynapse	Mitochondrion Mitochondrial Inner Membrane Membrane Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulatory Region Nucleic Acid Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Mitochondrial Fusion Protein Hexamerization Mitochondrial Protein Processing Mitochondrial Protein Catabolic Process Negative Regulation Of Apoptotic Process Neuronal Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways		ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Processing of SMDT1 Mitochondrial protein degradation Cellular response to mitochondrial stress
Drugs
Diseases
GWAS		Acne (severe) ( 30542056 24927181) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Falling risk ( 32999390) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 27863252 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 19862010 28017375 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Refractive error ( 32231278) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 1 diabetes ( 34012112) Type 2 diabetes ( 28869590 30297969 29358691 30718926 20581827 22885922 32499647 24509480) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Walking pace ( 33128006)	Shigella-associated diarrhea ( 33649051) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		25 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 FXR2 GMCL2 LMO1 MORF4L2 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 SIN3A SIRT1 SUZ12 TSC1 UBE2I YME1L1 ZBTB24	7 interacting genes: BCL11A MYOG OGT PSEN1 PSMG1 RNF26 UBC
Entrez ID		53335	10730
HPRD ID		05949	06981
Ensembl ID		ENSG00000119866	ENSG00000136758
Uniprot IDs		A0A2R8Y2E8 A0A2U3TZJ5 B4DT16 D9YZV9 D9YZW0 Q9H165	Q96TA2
PDB IDs		5VTB 6KI6 6U9Q 8DTN 8DTU 8THO 8TLO 9B4P 9BV0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Developmental Process Regulation Of Mitotic Cell Cycle Chromatin Silencing Complex Regulation Of Cell Population Proliferation Nuclear Receptor Activity Facultative Heterochromatin Formation Regulation Of Cell Cycle Regulation Of Primary Metabolic Process ESC/E(Z) Complex Heterochromatin Formation Epigenetic Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cellular Senescence Mononuclear Cell Differentiation Regulation Of Cell Motility Regulation Of Locomotion Leukocyte Activation HLH Domain Binding Leukocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Positive Regulation Of Response To Endoplasmic Reticulum Stress Cell Activation Cellular Response To Stress	Cellular Response To Oxygen-containing Compound Protein Modification Process Regulation Of ATP Metabolic Process Negative Regulation Of Axonogenesis Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Negative Regulation Of Core Promoter Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Proteasome Core Complex Assembly Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Nucleoplasm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Developmental Process Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Proteolysis Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Neuron Projection Development Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Neurogenesis Negative Regulation Of Protein-containing Complex Assembly Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Protein Homooligomerization Transcription Regulatory Region Nucleic Acid Binding Negative Regulation Of Neuron Maturation Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Axonogenesis Synaptic Vesicle Targeting Protein Glycosylation Negative Regulation Of Nervous System Development Negative Regulation Of Proteolysis Macromolecule Glycosylation Astrocyte Activation Involved In Immune Response Negative Regulation Of Dendrite Extension Negative Regulation Of Protein Oligomerization Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Sequestering Of Calcium Ion
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