TBX6 and PLA2G10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TBX6	PLA2G10
Name		T-box transcription factor 6	phospholipase A2 group X
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Prostaglandin Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Fertilization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Lipid Catabolic Process Arachidonate Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Hair Follicle Morphogenesis Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Intestinal Stem Cell Homeostasis Macrophage Activation Cholesterol Homeostasis Regulation Of Macrophage Activation Erythrocyte Maturation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonate Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonate Secretion Negative Regulation Of Cholesterol Efflux Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Acrosome Reaction
Pathways		Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		None	Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body fat distribution (arm fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Eosinophil count ( 27863252 32888494 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Multiple sclerosis ( 31604244 ) Red blood cell count ( 29403010 27863252 32888494 ) Reticulocyte count ( 32888494 ) Schizophrenia ( 29483656 25056061 ) Sum eosinophil basophil counts ( 27863252 )	Cholesteryl ester levels ( 31551469 )
Novel Interactors		1 novel interactors: DOC2A	1 novel interactors: GRIN2A
Interacting Genes		39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34	55 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXA1 HOXC8 HR HSF4 INCA1 KPRP KRTAP10-8 KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE1F LCE2A LCE2B LCE2D LCE3A LCE5A MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 PLSCR4 POU4F3 ROR2 SAXO4 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		6911	8399
HPRD ID		03888	04674
Ensembl ID		ENSG00000149922	ENSG00000069764
Uniprot IDs		O95947	O15496
PDB IDs		Not available	1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
GO Terms Enriched among Interactors		None	Keratinization Epidermis Development Tissue Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Protein Binding Chromatin