TBX6 and PRR20A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBX6	PRR20A
Description		T-box transcription factor 6	proline rich 20A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010 27863252 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 29483656 25056061) Sum eosinophil basophil counts ( 27863252)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596) Left ventricular mass (MTAG) ( 33495596) Systolic blood pressure ( 30224653) Total cholesterol levels ( 33339817)
Interacting Genes		39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34	95 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAB1 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GATA2 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NAA38 NCK2 NEDD9 NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU6F2 PRR20B PRR20C PRR20D PRR20E PRR34 PRR35 PTTG2 RBFOX1 RBM10 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SELENOV SH3RF1 SMAP1 SNRPB SNRPC SOX5 SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF488 ZNF683
Entrez ID		6911	122183
HPRD ID		03888	13445
Ensembl ID		ENSG00000149922	ENSG00000204919
Uniprot IDs		O95947	P86478 P86479 P86480 P86481 P86496
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Chromatin Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Splicing Sequence-specific DNA Binding Cell Fate Commitment Nucleoplasm MRNA Binding Myoblast Fate Commitment Regulation Of Neuron Differentiation Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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