TACC1 and CKAP5

Number of citations of the paper that reports this interaction (PMID 14603251)
16

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		TACC1	CKAP5
Gene Name		transforming, acidic coiled-coil containing protein 1	cytoskeleton associated protein 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Microtubule Cytoskeleton Intermediate Filament Cytoskeleton	Spindle Pole Gamma-tubulin Complex Centrosome Cytosol Microtubule Cytoskeleton Membrane Microtubule Plus-end Protein Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Cycle Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Regulation Of Microtubule-based Process Cell Division	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Spindle Organization Mitotic Nuclear Division Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity RNA Transport Centrosome Organization Cell Division
Pathways			Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		16 interactors: AURKA AURKB BTRC CKAP5 HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 PRKRIR SH2D4A SNRPG STX5 TDRD7 YEATS4	6 interactors: AURKA CACNA1A PTPRN2 TACC1 TOP1 USP19
Entrez ID		6867	9793
HPRD ID		10391	10830
Ensembl ID		ENSG00000147526	ENSG00000175216
Uniprot IDs		G8JLK4 O75410 Q5HYH0	Q14008
PDB IDs
Enriched GO Terms of Interacting Partners?		Spindle Stabilization Mitotic Cell Cycle Process Histone Modification Mitotic Cell Cycle Negative Regulation Of Protein Binding Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone-serine Phosphorylation Chromatin Modification Cell Cycle Process Negative Regulation Of Binding Mitotic Nuclear Division G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Spindle Organization Regulation Of Protein Stability Regulation Of Protein Binding Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Posttranscriptional Regulation Of Gene Expression Histone Phosphorylation Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Organization Positive Regulation Of Protein Catabolic Process Chromosome Organization Organelle Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Histone H4 Acetylation Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Proteasomal Protein Catabolic Process Regulation Of Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Neural Plate Formation Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Spindle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Cell Proliferation Golgi Organization Spindle Assembly Spindle Assembly Involved In Female Meiosis I Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Microtubule-based Process Diencephalon Development Centrosome Organization	Cell Division Negative Regulation Of Spindle Checkpoint Cerebellar Molecular Layer Development Vestibular Nucleus Development Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Stability Cell Growth Spindle Assembly Involved In Meiosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Spindle Stabilization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Hypoxia Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Cell Cycle Process Rhythmic Synaptic Transmission Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Oocyte Maturation Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Meiotic Spindle Organization Positive Regulation Of Cell Cycle Protein Localization To Centrosome Mitotic Centrosome Separation Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Negative Regulation Of Hormone Biosynthetic Process Pons Development Embryonic Cleavage Regulation Of Protein Catabolic Process Cerebellar Purkinje Cell Differentiation Interkinetic Nuclear Migration Organelle Localization Cerebellar Purkinje Cell Layer Morphogenesis Protein Localization To Cytoskeleton Histone-serine Phosphorylation Microtubule Cytoskeleton Organization Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Skeletal Muscle Tissue Development Reflex Behavioral Response To Pain Neurogenesis Regulation Of Cell Cycle Process
Tagcloud ?		acidic additionally amplification clinicopathological coil coiled correlation cytoplasmic dysregulation fda fish gc her2 immunohistochemistry indicator lymph maybe node occurs positive prognostic resected stage synergistic thought tnm transforming unclear valuable	abscission binucleated bridges centrosome chfr coil coiled converges cytokinetic division envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		acidic additionally amplification clinicopathological correlation cytoplasmic dysregulation fda fish gc her2 immunohistochemistry indicator lymph maybe node occurs positive prognostic resected stage synergistic thought tnm transforming unclear valuable	abscission binucleated bridges centrosome chfr converges cytokinetic division envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?		coil coiled