RRP8

Description		ribosomal RNA processing 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytosol Plasma Membrane RDNA Heterochromatin ENoSc Complex
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone H3K9me2/3 Reader Activity
	Biological Process	RDNA Heterochromatin Formation Chromatin Organization RRNA Processing Methylation Cellular Response To Glucose Starvation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Homeostasis Regulation Of G1 To G0 Transition
Pathways		SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		6 interacting genes: DVL3 MEOX2 OGT PICK1 SIRT1 SUV39H1
Entrez ID		23378
HPRD ID		13800
Ensembl ID		ENSG00000132275
Uniprot IDs		O43159
PDB IDs		2ZFU
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By Glucose Cellular Response To Glucose Starvation ENoSc Complex Cellular Response To Nutrient Levels RDNA Heterochromatin RDNA Heterochromatin Formation Chromatin Silencing Complex Response To Nutrient Levels Circadian Rhythm Facultative Heterochromatin Formation Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Starvation Response To Starvation Rhythmic Process Response To Decreased Oxygen Levels Regulation Of Cellular Senescence Response To Oxygen Levels Heterochromatin Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Energy Homeostasis Circadian Regulation Of Gene Expression Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Insulin Receptor Signaling Pathway NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Positive Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Regulation Of Glucose Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway NAD-dependent Protein Lysine Delactylase Activity Regulation Of Cellular Response To Testosterone Stimulus Behavioral Response To Starvation Negative Regulation Of Peptidyl-lysine Acetylation Histone H4K16 Deacetylase Activity, NAD-dependent Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Negative Regulation Of Prostaglandin Biosynthetic Process Protein Depropionylation Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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