RRP8

Gene Name		ribosomal RNA processing 8, methyltransferase, homolog (yeast)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Plasma Membrane RDNA Heterochromatin
	Molecular Function	Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Methylated Histone Binding Poly(A) RNA Binding
	Biological Process	Chromatin Silencing At RDNA Transcription, DNA-templated RRNA Processing Gene Expression Chromatin Modification Methylation Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription By Glucose Positive Regulation Of Cell Cycle Arrest Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: SIRT1 SUV39H1
Entrez ID		23378
HPRD ID		13800
Ensembl ID
Uniprot IDs		O43159
PDB IDs		2ZFU
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Chromatin Silencing Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Cellular Response To Oxygen Levels RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Regulation Of Gene Expression, Epigenetic Establishment Of Chromatin Silencing Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Cellular Response To Testosterone Stimulus Peptidyl-lysine Modification Response To Hypoxia Behavioral Response To Starvation Rhythmic Process Ribonucleoprotein Complex Biogenesis Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Histone Modification Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cellular Senescence NcRNA Metabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Positive Regulation Of Macrophage Apoptotic Process Histone H3-K9 Dimethylation Viral Process Peptidyl-lysine Deacetylation Methylation-dependent Chromatin Silencing Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of MHC Class II Biosynthetic Process Chromatin Modification Positive Regulation Of Cell Aging Triglyceride Mobilization Cellular Triglyceride Homeostasis Negative Regulation Of Cellular Senescence Positive Regulation Of Myeloid Cell Apoptotic Process Histone H3-K9 Trimethylation Chromatin Organization Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ovulation From Ovarian Follicle Peptidyl-lysine Dimethylation Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Bile Acid Biosynthetic Process
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