CNR1 and GNAI1

Number of citations of the paper that reports this interaction (PMID 11168387)
12

Data Source:
HPRD (in vivo)

		CNR1	GNAI1
Gene Name		cannabinoid receptor 1 (brain)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Growth Cone Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome
	Molecular Function	Cannabinoid Receptor Activity Drug Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs		Dronabinol Nabilone Rimonabant
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET	57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		1268	2770
HPRD ID		00259	00756
Ensembl ID		ENSG00000118432	ENSG00000127955
Uniprot IDs		P21554 S5TLS4	P63096
PDB IDs		1LVQ 1LVR 2B0Y 2KOE	1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Cell Surface Receptor Signaling Pathway Wound Healing Cell Activation Response To Wounding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Vesicle Fusion Regulation Of Adenylate Cyclase Activity Cell Division Regulation Of Cyclase Activity Signal Transduction Organelle Fusion Signaling Regulation Of CAMP Biosynthetic Process Cell Communication Regulation Of CAMP Metabolic Process Membrane Fusion Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Behavior Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Vesicle Organization Regulation Of Catalytic Activity Myoblast Proliferation Response To Stimulus Hepatocyte Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Endothelial Cell Chemotaxis Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death Endothelial Cell Morphogenesis Cell Cycle Regulation Of Hydrogen Peroxide-induced Cell Death Adenosine Receptor Signaling Pathway Mesenchymal-epithelial Cell Signaling	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process
Tagcloud ?		addicts alcohol alleles allocation amplitude attentional blocking cannabinoid contributed dependence electrodes erp evoked frontal homozygosity homozygous intoxication lobe lobes manova marijuana memory microsatellite reflects repeat resource variance wave working	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		addicts alcohol alleles allocation amplitude attentional blocking cannabinoid contributed dependence electrodes erp evoked frontal homozygosity homozygous intoxication lobe lobes manova marijuana memory microsatellite reflects repeat resource variance wave working	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?