SRP14 and NSFL1C

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SRP14	NSFL1C
Gene Name		signal recognition particle 14kDa (homologous Alu RNA binding protein)	NSFL1 (p97) cofactor (p47)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Intercellular Bridge Extracellular Vesicular Exosome	Nucleoplasm Chromosome Cytoplasm Golgi Stack Cytosol Plasma Membrane Intermediate Filament Cytoskeleton
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding Poly(A) RNA Binding	Protein Binding Lipid Binding Protein Phosphatase Type 1 Regulator Activity Ubiquitin Binding
	Biological Process	Translation Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process Protein Targeting To ER	Autophagic Vacuole Assembly Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Membrane Fusion
Pathways		Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CALM1 IL7R NSFL1C SRP9	14 interactors: ANP32A CDK1 DBI FAM32A GLMN GSK3B LIPE NGLY1 PHAX RPL22 SRP14 STX5 TARDBP VCP
Entrez ID		6727	55968
HPRD ID		02831	09425
Ensembl ID		ENSG00000140319	ENSG00000088833
Uniprot IDs		P37108	Q53FE8 Q9UNZ2
PDB IDs		1E8O 1E8S 1RY1	1SS6
Enriched GO Terms of Interacting Partners?		Membrane Organization Interleukin-7-mediated Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Translational Elongation Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Nuclear Envelope Reassembly Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Mediated Immunity Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Adaptive Immune Response Response To Mineralocorticoid Regulation Of Nitric-oxide Synthase Activity	Cytoplasmic Transport Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Intracellular Transport Cellular Localization Positive Regulation Of Protein Transport Protein Localization Establishment Of Localization In Cell Cellular Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Protein Localization Response To Endoplasmic Reticulum Stress Intracellular Protein Transport Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Transport Nucleocytoplasmic Transport Nuclear Transport Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteolysis Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Pronuclear Fusion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat Positive Regulation Of Transport Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Cell Differentiation Regulation Of Protein Localization Organelle Fusion Cellular Macromolecule Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development SnRNA Export From Nucleus Superior Temporal Gyrus Development Membrane Organization SRP-dependent Cotranslational Protein Targeting To Membrane Triglyceride Metabolic Process Cotranslational Protein Targeting To Membrane ER To Golgi Vesicle-mediated Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Neutral Lipid Metabolic Process Re-entry Into Mitotic Cell Cycle Golgi Disassembly Negative Regulation Of Neuron Maturation
Tagcloud ?			anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?			anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?