SRP14

Gene Name		signal recognition particle 14kDa (homologous Alu RNA binding protein)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Intercellular Bridge Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding Poly(A) RNA Binding
	Biological Process	Translation Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process Protein Targeting To ER
Pathways		Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Ewing sarcoma ( 22327514) Obesity-related traits ( 23251661)
Protein-protein Interactions		4 interactors: CALM1 IL7R NSFL1C SRP9
Entrez ID		6727
HPRD ID		02831
Ensembl ID		ENSG00000140319
Uniprot IDs		P37108
PDB IDs		1E8O 1E8S 1RY1
Enriched GO Terms of Interacting Partners?		Membrane Organization Interleukin-7-mediated Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Translational Elongation Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Nuclear Envelope Reassembly Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Mediated Immunity Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Cell Activation Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Adaptive Immune Response Response To Mineralocorticoid Regulation Of Nitric-oxide Synthase Activity
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