SPIB and CEBPB

Number of citations of the paper that reports this interaction (PMID 10196196)
10

Data Source:
HPRD (in vitro)

		SPIB	CEBPB
Gene Name		Spi-B transcription factor (Spi-1/PU.1 related)	CCAAT/enhancer binding protein (C/EBP), beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Condensed Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Inflammatory Response Immune Response Neuron Differentiation Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Amino Acid Stimulus
Pathways			Transcriptional regulation of white adipocyte differentiation Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Primary biliary cirrhosis ( 21399635 20639880)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		19 interactors: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37	54 interactors: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIM28
Entrez ID		6689	1051
HPRD ID		06007	01801
Ensembl ID		ENSG00000269404	ENSG00000172216
Uniprot IDs		Q01892	P17676
PDB IDs			1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Nitrogen Compound Metabolic Process Death Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Chromosome Organization DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Binding Myeloid Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Process Cellular Metabolic Process System Development Developmental Process Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus
Tagcloud ?		abc amplify attractive augmenting btk card11 cereblon dlbcl dlbcls downregulates fashion ibrutinib ifnbeta inspire irf4 irf7 killing kills lenalidomide lethal lymphomas myd88 owing prosurvival repressing sparing synergizes synthetically transactivating	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		abc amplify attractive augmenting btk card11 cereblon dlbcl dlbcls downregulates fashion ibrutinib ifnbeta inspire irf4 irf7 killing kills lenalidomide lethal lymphomas myd88 owing prosurvival repressing sparing synergizes synthetically transactivating	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?