SPIB and SSB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPIB	SSB
Gene Name		Spi-B transcription factor (Spi-1/PU.1 related)	Sjogren syndrome antigen B (autoantigen La)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Ribonucleoprotein Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding	TRNA Binding Nucleotide Binding MRNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation	TRNA Modification Histone MRNA Metabolic Process
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Termination RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Primary biliary cirrhosis ( 21399635 20639880)
Protein-Protein Interactions		19 interactors: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37	9 interactors: APP CSNK2A1 CSNK2B GZMH HMGA1 IL7R NCL SPIB SPP1
Entrez ID		6689	6741
HPRD ID		06007	00168
Ensembl ID		ENSG00000269404	ENSG00000138385
Uniprot IDs		Q01892	P05455
PDB IDs			1OWX 1S79 1S7A 1YTY 1ZH5 2VOD 2VON 2VOO 2VOP
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Nitrogen Compound Metabolic Process Death Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Chromosome Organization DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Binding Myeloid Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process	Chemotaxis Developmental Process Response To External Stimulus Axon Guidance Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cell Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Interleukin-7-mediated Signaling Pathway Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Oncogene-induced Cell Senescence Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Locomotion Axonogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Cell Size Collateral Sprouting In Absence Of Injury Senescence-associated Heterochromatin Focus Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Growth Cell Growth Neuron Projection Morphogenesis Positive Regulation Of Cellular Senescence System Development Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Generation Of Neurons Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neurogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Negative Regulation Of Chromatin Silencing Negative Regulation Of Axon Regeneration Positive Regulation Of Activin Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Neuron Projection Development Regulation Of Mitotic Cell Cycle Phase Transition Multicellular Organismal Development Cell Projection Morphogenesis Positive Regulation Of Cell Aging Adiponectin-activated Signaling Pathway Regulation Of Cell Cycle Phase Transition Cell Part Morphogenesis
Tagcloud ?		abc amplify attractive augmenting btk card11 cereblon dlbcl dlbcls downregulates fashion ibrutinib ifnbeta inspire irf4 irf7 killing kills lenalidomide lethal lymphomas myd88 owing prosurvival repressing sparing synergizes synthetically transactivating	advocate anticollagen asymptomatic autoantibodies autoantibody blindly cardiolipin certified dealing dsdna ganglioside gm2 harbored israeli la liabilities nc phosphatidylserine polyclonality preponderance pyruvate questioning rheumatological rheumatologist rnp silicone ssa ssdna symptomatic
Tagcloud (Difference) ?		abc amplify attractive augmenting btk card11 cereblon dlbcl dlbcls downregulates fashion ibrutinib ifnbeta inspire irf4 irf7 killing kills lenalidomide lethal lymphomas myd88 owing prosurvival repressing sparing synergizes synthetically transactivating	advocate anticollagen asymptomatic autoantibodies autoantibody blindly cardiolipin certified dealing dsdna ganglioside gm2 harbored israeli la liabilities nc phosphatidylserine polyclonality preponderance pyruvate questioning rheumatological rheumatologist rnp silicone ssa ssdna symptomatic
Tagcloud (Intersection) ?