FBXL17 and SPAST

Number of citations of the paper that reports this interaction (PubMedID 35869491)
35

Data Source:
BioGRID (enzymatic study)

		FBXL17	SPAST
Description		F-box and leucine rich repeat protein 17	spastin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SCF Ubiquitin Ligase Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission
Pathways		Regulation of BACH1 activity	Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) smoking initiation in schizophrenia ( 33691233) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		40 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KEAP1 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SPAST SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 USP25 ZMYM2 ZNF350	11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20
Entrez ID		64839	6683
HPRD ID		10950	05044
Ensembl ID		ENSG00000145743	ENSG00000021574
Uniprot IDs		Q9UF56	A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0
PDB IDs		6W66 6WCQ 8UAH 8UBT 8UBU 8UBV	3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J
Enriched GO Terms of Interacting Partners?		Proteolysis Cul3-RING Ubiquitin Ligase Complex Protein Metabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Negative Regulation Of Response To Oxidative Stress Peptidase Activator Activity Neural Crest Formation	MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?