RTN1 and SPAST

Number of citations of the paper that reports this interaction (PMID 16602018)
13

Data Source:
HPRD (in vitro, in vivo)

		RTN1	SPAST
Gene Name		reticulon 1	spastin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Centrosome Spindle Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Neuron Differentiation	Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Axonogenesis Metabolic Process Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Protein Hexamerization Microtubule Severing Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BCL2L1 FAM160A2 HDAC8 PLEKHF2 SDCBP SPAST UGCG	4 interactors: CHMP1B IST1 RTN1 SSNA1
Entrez ID		6252	6683
HPRD ID		02921	05044
Ensembl ID		ENSG00000139970	ENSG00000021574
Uniprot IDs		A8K3B9 Q16799	E5KRP5 E5KRP6 Q9UBP0
PDB IDs			3EAB 3VFD
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Apoptotic Process In Bone Marrow Glucosylceramide Biosynthetic Process Cytokinesis Intracellular Transport Organelle Organization Cytokinesis, Completion Of Separation Mitotic Cell Cycle Positive Regulation Of Extracellular Vesicular Exosome Assembly Suppression By Virus Of Host Apoptotic Process Regulation Of Cohesin Localization To Chromatin Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Depolymerization Glucosylceramide Metabolic Process Establishment Of Localization In Cell Cell Part Morphogenesis Regulation Of Extracellular Vesicular Exosome Assembly Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitotic Cytokinetic Process Protein Hexamerization Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cellular Localization Cell Cycle Process Cellular Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Cellular Response To Virus Microtubule Severing Modulation By Virus Of Host Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis Cellular Response To Gamma Radiation Hepatocyte Apoptotic Process Regulation Of Sister Chromatid Cohesion Cell Cycle Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Cell Separation After Cytokinesis Positive Regulation Of Protein Depolymerization Transport Positive Regulation Of Organelle Organization Protein Transport Early Endosome To Late Endosome Transport Negative Regulation Of Protein Localization To Plasma Membrane Cell Division Vesicle-mediated Transport Mitochondrion Morphogenesis Modulation By Virus Of Host Morphology Or Physiology	Cytokinesis Viral Capsid Secondary Envelopment Cell Cycle Process Viral Release From Host Cell Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Abscission Positive Regulation Of Collateral Sprouting Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cell Division Protein Localization Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Metaphase Plate Congression Mitotic Cell Cycle Intraciliary Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Receptor Clustering
Tagcloud ?		astrocyte clues constitute exert explore fi fl galactosidase glutathione homo immuno interacting library manf media mesencephalic neurotrophic proapoptotic pull regular reticular reticulons rtns sapiens screen speci transferase uorescence verified	accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness
Tagcloud (Difference) ?		astrocyte clues constitute exert explore fi fl galactosidase glutathione homo immuno interacting library manf media mesencephalic neurotrophic proapoptotic pull regular reticular reticulons rtns sapiens screen speci transferase uorescence verified	accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness
Tagcloud (Intersection) ?