SNAPC1 and HAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNAPC1	HAT1
Description		small nuclear RNA activating complex polypeptide 1	histone acetyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus SnRNA-activating Protein Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix Protein-containing Complex
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Sequence-specific DNA Binding	Histone Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III	Chromatin Organization Nucleosome Assembly Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Chromosome Organization
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	HATs acetylate histones
Drugs
Diseases
GWAS		Chronotype ( 30696823) Metabolite levels ( 23823483)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		14 interacting genes: CCDC6 EXOC8 HAT1 HOXA10 HSF2BP NR2E3 RB1 RHOXF2 SAAL1 SNAPC3 SNAPC4 SNAPC5 TBP TRIM29	23 interacting genes: ACAA1 CEBPA EZH2 H2AC20 H3-4 H3C1 H4C14 H4C16 HTR2B KANK4 MEOX2 MORN5 PRKAA2 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		6617	8520
HPRD ID		08998	04339
Ensembl ID		ENSG00000023608	ENSG00000128708
Uniprot IDs		B2RC42 Q16533	A0AAG2UVM1 O14929
PDB IDs		7XUR 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	2P0W 6VO5 9MJG
Enriched GO Terms of Interacting Partners?		RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III SnRNA Transcription By RNA Polymerase III Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription DNA-templated Transcription SnRNA-activating Protein Complex RNA Polymerase II General Transcription Initiation Factor Activity SnRNA Metabolic Process RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Core Promoter Sequence-specific DNA Binding Nucleoplasm Male Gamete Generation Spermatogenesis RNA Metabolic Process Macromolecule Biosynthetic Process DNA Binding Gamete Generation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Chromatin Bent DNA Binding DNA-templated Transcription Initiation Chromatin Lock Complex Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Positive Regulation Of Synoviocyte Proliferation Nucleic Acid Metabolic Process	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Chromosome, Telomeric Region Protein-DNA Complex Assembly DNA Binding Nucleosome Assembly Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Cell Differentiation Sequence-specific DNA Binding Chromatin Remodeling Chromosome Nucleosome Organization Telomere Organization Protein Localization To Chromatin Chromatin Organization Regulation Of Cell Differentiation Nucleus Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Developmental Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein-containing Complex Cardiac Muscle Hypertrophy Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Hypertrophy Regulation Of Cell Development Positive Regulation Of Cartilage Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Acetate CoA-transferase Activity Phenylacetate Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Chromosome Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Coated Vesicle Membrane
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