FUNDC2 and TMEM154

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FUNDC2	TMEM154
Description		FUN14 domain containing 2	transmembrane protein 154
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane	Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding
	Biological Process	Autophagy Of Mitochondrion Regulation Of Platelet Activation Intracellular Triglyceride Homeostasis
Pathways
Drugs
Diseases
GWAS			Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Hip circumference ( 28552196) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647)
Interacting Genes		40 interacting genes: AQP6 ARL13B ARL15 ASCC2 ATP13A2 CD79A CIDEB COX20 CRB3 CYB5R3 EBP EIF6 ERGIC3 EVI2B FAM209A FCER1G FGF14 GPR152 KCNJ6 KIR2DL3 MGST3 NACA NSF NUDT21 REEP4 RETREG3 RGS1 SAT1 SDR16C5 SLC10A6 SLC16A10 SLC66A2 SLC71A2 STOM SYT2 TMEM14B TMEM154 TMX2 TP53I3 USP13	11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1
Entrez ID		65991	201799
HPRD ID		06586	08719
Ensembl ID		ENSG00000165775	ENSG00000170006
Uniprot IDs		Q9BWH2	Q6P9G4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity
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