STIM1 and STIM2

Number of citations of the paper that reports this interaction (PMID 11463338)
75

Data Source:
HPRD (in vivo, in vitro)

		STIM1	STIM2
Gene Name		stromal interaction molecule 1	stromal interaction molecule 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding Microtubule Plus-end Binding	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Store-operated Calcium Channel Activity
	Biological Process	Detection Of Calcium Ion Calcium Ion Transport Blood Coagulation Activation Of Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transport	Cellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Platelet homeostasis Elevation of cytosolic Ca2+ levels Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Platelet calcium homeostasis Adaptive Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		1 interactors: STIM2	3 interactors: CALM1 PRPF40A STIM1
Entrez ID		6786	57620
HPRD ID		05803	11609
Ensembl ID		ENSG00000167323	ENSG00000109689
Uniprot IDs		E9PNJ4 E9PQJ4 G0XQ39 Q13586	A6H8L7 B3KUB5 Q9P246
PDB IDs		2K60 3TEQ	2L5Y
Enriched GO Terms of Interacting Partners?		Activation Of Store-operated Calcium Channel Activity Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Positive Regulation Of Calcium Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Calcium Ion Transmembrane Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Cellular Metal Ion Homeostasis Regulation Of Ion Transmembrane Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Ion Transport Cellular Homeostasis Positive Regulation Of Transport	Detection Of Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Cytokinesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Response To Calcium Ion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Metal Ion Store-operated Calcium Entry Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Detection Of Chemical Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Store-operated Calcium Channel Activity Response To Inorganic Substance Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Cycle Process Regulation Of Store-operated Calcium Channel Activity Regulation Of Store-operated Calcium Entry Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Detection Of Stimulus Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Regulation Of Ion Transport Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Response To Wounding
Tagcloud ?		ampa ampar beginning camp contact coupling debated dendritic endocytosis excitatory exo glua1 influences junctions mammals operated organizer paralogue pka pm reside shapes soce spines stim2 stims store synapses triggers	ampa ampar beginning camp contact coupling debated dendritic endocytosis excitatory exo glua1 influences junctions mammals operated organizer paralogue pka pm reside shapes soce spines stim1 stims store synapses triggers
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		ampa ampar beginning camp contact coupling debated dendritic endocytosis excitatory exo glua1 influences junctions mammals operated organizer paralogue pka pm reside shapes soce spines stim1 stim2 stims store synapses triggers