STIM1

Name	stromal interaction molecule 1
Structure
Novel Interactors	2 novel interactors: RRM1 TH
Interactors	6 interactors: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2 TSPAN18
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Microtubule Plasma Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Store-operated Calcium Entry Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Store-operated Calcium Entry
Pathways	Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GWAS	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Calcium levels ( 29403010 ) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439 ) Hemoglobin ( 32888494 ) Malaria ( 31844061 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Platelet distribution width ( 27863252 32888494 ) Systemic lupus erythematosus ( 33272962 ) Waist circumference ( 34074324 )
Entrez ID	6786
HPRD ID	05803
Ensembl ID	ENSG00000167323
Uniprot IDs	A0A8V8TMF0 A0A8V8TMG1 A0A8V8TNW0 A0A8V8TP73 E9PRZ7 G0XQ39 H0YDB2 Q13586
PDB IDs	2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
GO Terms Enriched among Interactors ?	Type II Interferon Receptor Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Lysine Transport L-ornithine Transmembrane Transport L-histidine Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane Synaptic Vesicle Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Tyrosine 3-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Dopamine Biosynthetic Process From Tyrosine Negative Regulation Of SREBP Signaling Pathway SREBP-SCAP-Insig Complex SREBP-SCAP Complex Retention In Endoplasmic Reticulum Activation Of Store-operated Calcium Channel Activity L-lysine Transmembrane Transport Hyaloid Vascular Plexus Regression Positive Regulation Of Store-operated Calcium Channel Activity