INTS3 and ZBTB14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		INTS3	ZBTB14
Description		integrator complex subunit 3	zinc finger and BTB domain containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Integrator Complex Site Of Double-strand Break SOSS Complex INTAC Complex	Nucleus Nucleoplasm Nucleolus Cytosol Aggresome
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II Mitotic G2/M Transition Checkpoint RNA Polymerase II Transcription Initiation Surveillance	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Kidney Development Regulation Of Immune System Process Heart Valve Development Cardiac Septum Development Negative Regulation Of DNA-templated Transcription Coronary Vasculature Development
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vegetable consumption ( 33693791)	Cerebral amyloid deposition (PET imaging) ( 26252872) Lacunar stroke ( 33773637)
Interacting Genes		4 interacting genes: APP CTDP1 SUMO2 ZBTB14	51 interacting genes: AP1M1 ATP5PO ATRIP BAZ2B BYSL C2orf68 CAPN6 CBX8 CDK16 CDKL3 CEP19 DDX6 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 KAT5 MAD2L1BP MFAP1 MORF4L2 MRPL11 NAA10 NAA11 OGT PIN1 PNKP POLR2L PRMT1 RNASEH2B RNPS1 RPA1 RPA2 RPL9 RPS25 RPS7 SCNM1 SDCBP SNRPB2 SYT16 TCEANC TRIM55 TSTD2 TXN2 WNT9A ZBTB21 ZCCHC10 ZMAT2
Entrez ID		65123	7541
HPRD ID		08644	03674
Ensembl ID		ENSG00000143624	ENSG00000198081
Uniprot IDs		Q68E01	B2R850 O43829
PDB IDs		4OWT 4OWW 4OWX 6WLG 7BV7 8HPP 8RBZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Axon Midline Choice Point Recognition Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling TFIIF-class Transcription Factor Complex Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of RNA Metabolic Process Axon Choice Point Recognition RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Developmental Growth Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Nucleobase-containing Compound Metabolic Process Tat Protein Binding Antifungal Humoral Response	Nucleoplasm Nucleus Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Regulation Of DNA Repair Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Site Of Double-strand Break Protein N-terminal-serine Acetyltransferase Activity Nucleotide-excision Repair Protein Binding DNA Repair Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Mismatch Repair NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Acetylation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination G-rich Strand Telomeric DNA Binding RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome N-terminal Protein Amino Acid Acetylation Clathrin Adaptor Complex Organelle Assembly RNA Splicing, Via Transesterification Reactions DNA Replication Factor A Complex Cytoplasmic Translation RNA Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Process
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