INTS3

Description		integrator complex subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Integrator Complex Site Of Double-strand Break SOSS Complex INTAC Complex
	Molecular Function	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II Mitotic G2/M Transition Checkpoint RNA Polymerase II Transcription Initiation Surveillance
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vegetable consumption ( 33693791)
Interacting Genes		4 interacting genes: APP CTDP1 SUMO2 ZBTB14
Entrez ID		65123
HPRD ID		08644
Ensembl ID		ENSG00000143624
Uniprot IDs		Q68E01
PDB IDs		4OWT 4OWW 4OWX 6WLG 7BV7 8HPP 8RBZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Axon Midline Choice Point Recognition Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling TFIIF-class Transcription Factor Complex Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of RNA Metabolic Process Axon Choice Point Recognition RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Developmental Growth Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Nucleobase-containing Compound Metabolic Process Tat Protein Binding Antifungal Humoral Response
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