MRPS6 and RNF181

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MRPS6	RNF181
Gene Name		mitochondrial ribosomal protein S6	ring finger protein 181
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Small Ribosomal Subunit
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Small Ribosomal Subunit RRNA Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Protein Autoubiquitination
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990) Myocardial infarction (early onset) ( 19198609)	Prostate cancer ( 21743467)
Protein-Protein Interactions		8 interactors: APP KIAA1377 LRIF1 MKRN3 RNF181 SREBF2 SRPK2 STAT5A	19 interactors: BIRC2 BTG1 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2U VPS11 ZMYND10
Entrez ID		64968	51255
HPRD ID		11374	14236
Ensembl ID		ENSG00000243927
Uniprot IDs		P82932	Q9P0P0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Cycle Positive Regulation Of Mast Cell Differentiation Nuclear Speck Organization Regulation Of Multicellular Organism Growth Cholesterol Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Positive Regulation Of Gene Expression Negative Regulation Of Mast Cell Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Creatinine Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Mast Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Mast Cell Proliferation Isoleucine Metabolic Process Axon Choice Point Recognition Allantoin Metabolic Process Gene Expression Cellular Response To Laminar Fluid Shear Stress Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Regulation Of Cell Cycle Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Activation Neuron Remodeling Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Cholesterol Transport Succinate Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Developmental Growth Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Response To Low-density Lipoprotein Particle Positive Regulation Of Interleukin-2 Biosynthetic Process	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Protein Modification Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Oxygen Levels Response To Hypoxia Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Ligase Activity Negative Regulation Of Necroptotic Process
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