SIM2 and ARNT2

Number of citations of the paper that reports this interaction (PMID 14701734)
30

Data Source:
BioGRID (two hybrid)

		SIM2	ARNT2
Gene Name		single-minded family bHLH transcription factor 2	aryl-hydrocarbon receptor nuclear translocator 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development	Response To Hypoxia In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Central Nervous System Development Brain Development Positive Regulation Of Cell Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ARNT ARNT2 PARK2	59 interactors: ADAMTSL4 APP ARNT BZRAP1 CALCOCO2 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 GOLGA2 HIF1A IKZF3 KIFC3 LZTS2 MAGEA4 MEIS2 MEOX2 MIPOL1 MTUS2 NCOA3 NDE1 NPAS2 NPAS3 NPAS4 PDE4DIP PLSCR1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM2 SORBS3 SPAG5 SSBP3 SSX2IP SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRAF4 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 USHBP1 USP7 VPS52 ZNF341
Entrez ID		6493	9915
HPRD ID		02935	06915
Ensembl ID		ENSG00000159263	ENSG00000172379
Uniprot IDs		Q14190	Q7Z3A3 Q86TN1 Q9HBZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Linear Polyubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Transcription, DNA-templated Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death RNA Biosynthetic Process Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Positive Regulation Of Cellular Metabolic Process Dopamine Transport In Utero Embryonic Development Positive Regulation Of Hormone Biosynthetic Process Aggresome Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Positive Regulation Of Protein Sumoylation Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic MRNA Transcription Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Microtubule-based Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Localization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cellular Process Regulation Of Signal Transduction Microtubule Cytoskeleton Organization Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process NIK/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Component Assembly Embryonic Placenta Development Organelle Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Microtubule-based Transport Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Protein Homodimerization Activity Cytoskeleton-dependent Intracellular Transport Regulation Of DNA-templated Transcription In Response To Stress
Tagcloud ?		clathrin cns colocalized confocal critical deficits ds elusive endocytosis exacerbates exact hybrid immunoprecipitation interacted laser learning mad2b mediate microscopy minded mitotic nervous neurons overexpression pathophysiological scanning thereby thought transferrin	adenovirus ahr arises aromatic aryl bhlh cbp conveys dioxin e1a extensively gst heterodimer hlf hybrid hydrocarbon hydrocarbons interacted metabolizing methylcholanthrene partner pas pull sim somehow tetrachlorodibenzo transactivation translocator
Tagcloud (Difference) ?		clathrin cns colocalized confocal critical deficits ds elusive endocytosis exacerbates exact immunoprecipitation laser learning mad2b mediate microscopy minded mitotic nervous neurons overexpression pathophysiological scanning thereby thought transferrin	adenovirus ahr arises aromatic aryl bhlh cbp conveys dioxin e1a extensively gst heterodimer hlf hydrocarbon hydrocarbons metabolizing methylcholanthrene partner pas pull sim somehow tetrachlorodibenzo transactivation translocator
Tagcloud (Intersection) ?		hybrid interacted