ADCY4 and C1orf50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADCY4	C1orf50
Description		adenylate cyclase 4	chromosome 1 open reading frame 50
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite	Cellular_component
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Protein Kinase C Binding Protein Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction	Biological_process
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin
Diseases
GWAS		Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		5 interacting genes: C1orf50 ESRRG PPARG TRIM54 TTC23	14 interacting genes: ADCY4 AHCY APPBP2 CRX EIF2B1 EPM2AIP1 INCA1 LRP2BP MEOX1 MEOX2 NTAQ1 REL TCF4 UBC
Entrez ID		196883	79078
HPRD ID		11614	14714
Ensembl ID		ENSG00000129467	ENSG00000164008
Uniprot IDs		Q86TZ7 Q8NFM4	Q9BV19
PDB IDs
Enriched GO Terms of Interacting Partners?		Retinoic Acid Receptor Signaling Pathway Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion AF-2 Domain Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of Lipoprotein Transport Arachidonate Binding Negative Regulation Of Mitochondrial Fission Negative Regulation Of Type II Interferon-mediated Signaling Pathway LBD Domain Binding Prostaglandin Receptor Activity DNA Binding Domain Binding Estrogen Response Element Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Extracellular Matrix Assembly STAT Family Protein Binding Regulation Of Connective Tissue Replacement Alpha-actinin Binding	Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Segment Specification Somite Development Nucleus DNA-binding Transcription Factor Activity
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