STIL and USP9X

Number of citations: 76 (PubMedID 31197030)
Data Source: BioGRID (enzymatic study)

		STIL	USP9X
Name		STIL centriolar assembly protein	ubiquitin specific peptidase 9 X-linked
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cell Cortex Ciliary Basal Body Procentriole Replication Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection
	Molecular Function	Protein Binding Identical Protein Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Embryonic Axis Specification In Utero Embryonic Development Neural Tube Closure Heart Looping Mitotic Spindle Organization Smoothened Signaling Pathway Determination Of Left/right Symmetry Neural Tube Development Forebrain Development Notochord Development Microtubule Organizing Center Organization Floor Plate Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Centrosome Duplication Regulation Of Mitotic Spindle Organization Protein Localization To Centrosome Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation
Pathways		None	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Diseases		Primary microcephaly (MCPH)	None
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Clozapine-induced agranulocytosis ( 25187353 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Migraine ( 27322543 )
Novel Interactors		None recorded	1 novel interactors: RPGR
Interacting Genes		2 interacting genes: PIN1 USP9X	32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL
Entrez ID		6491	8239
HPRD ID		01627	02091
Ensembl ID		ENSG00000123473	ENSG00000124486
Uniprot IDs		A0A0A0MR87 B7ZLW5 E9PSF2 Q15468 Q5T0C7 Q7Z626	A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008
PDB IDs		4YYP 5LHW 5LHZ 8OYK 8OYL	5VBD 5WCH 7YXX 7YXY
GO Terms Enriched among Interactors		Cis-trans Isomerase Activity Negative Regulation Of Protein Catabolic Process K11-linked Deubiquitinase Activity Protein Stabilization Regulation Of Protein Catabolic Process Protein Peptidyl-prolyl Isomerization Regulation Of Protein Stability Establishment Of Protein Localization To Organelle Phosphothreonine Residue Binding Negative Regulation Of Catabolic Process Phosphoserine Residue Binding Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Supramolecular Fiber Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling DNA Alkylation Repair Positive Regulation Of TORC2 Signaling Ubiquitin Ligase Activator Activity Co-SMAD Binding Regulation Of TORC2 Signaling Protein Import Into Peroxisome Matrix Molecular Sequestering Activity K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Establishment Of Protein Localization To Peroxisome Microtubule Polymerization Peroxisomal Membrane Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Protein Targeting To Mitochondrion Postsynaptic Cytosol Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Amyloid-beta Formation Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Amyloid Fibril Formation Peroxisome Organization Intracellular Protein Transmembrane Transport Peptidyl-prolyl Cis-trans Isomerase Activity Microtubule Polymerization Or Depolymerization Phosphoprotein Binding Establishment Of Protein Localization Regulation Of Amyloid-beta Formation Tau Protein Binding	Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration