STIL

Name	STIL centriolar assembly protein
Structure
Interactors	2 interactors: PIN1 USP9X
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cell Cortex Ciliary Basal Body Procentriole Replication Complex
	Molecular Function	Protein Binding Identical Protein Binding
	Biological Process	Embryonic Axis Specification In Utero Embryonic Development Neural Tube Closure Heart Looping Mitotic Spindle Organization Smoothened Signaling Pathway Determination Of Left/right Symmetry Neural Tube Development Forebrain Development Notochord Development Microtubule Organizing Center Organization Floor Plate Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Centrosome Duplication Regulation Of Mitotic Spindle Organization Protein Localization To Centrosome Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Spindle Assembly
Diseases	Primary microcephaly (MCPH)
GWAS	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Clozapine-induced agranulocytosis ( 25187353 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Hip circumference adjusted for BMI ( 34021172 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	6491
HPRD ID	01627
Ensembl ID	ENSG00000123473
Uniprot IDs	A0A0A0MR87 B7ZLW5 E9PSF2 Q15468 Q5T0C7 Q7Z626
PDB IDs	4YYP 5LHW 5LHZ 8OYK 8OYL
GO Terms Enriched among Interactors ?	Cis-trans Isomerase Activity Negative Regulation Of Protein Catabolic Process K11-linked Deubiquitinase Activity Protein Stabilization Regulation Of Protein Catabolic Process Protein Peptidyl-prolyl Isomerization Regulation Of Protein Stability Establishment Of Protein Localization To Organelle Phosphothreonine Residue Binding Negative Regulation Of Catabolic Process Phosphoserine Residue Binding Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Supramolecular Fiber Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling DNA Alkylation Repair Positive Regulation Of TORC2 Signaling Ubiquitin Ligase Activator Activity Co-SMAD Binding Regulation Of TORC2 Signaling Protein Import Into Peroxisome Matrix Molecular Sequestering Activity K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Establishment Of Protein Localization To Peroxisome Microtubule Polymerization Peroxisomal Membrane Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Protein Targeting To Mitochondrion Postsynaptic Cytosol Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Amyloid-beta Formation Protein K63-linked Deubiquitination Negative Regulation Of Cilium Assembly Receptor Recycling Deubiquitinase Activity Amyloid Fibril Formation Peroxisome Organization Intracellular Protein Transmembrane Transport Peptidyl-prolyl Cis-trans Isomerase Activity Microtubule Polymerization Or Depolymerization Phosphoprotein Binding Establishment Of Protein Localization Regulation Of Amyloid-beta Formation Tau Protein Binding