AGXT2 and ALDOB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AGXT2	ALDOB
Name		alanine--glyoxylate aminotransferase 2	aldolase, fructose-bisphosphate B
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Centriolar Satellite Extracellular Exosome
	Molecular Function	Alanine-glyoxylate Transaminase Activity Transaminase Activity Beta-alanine:pyruvate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity Identical Protein Binding ATPase Binding Molecular Adaptor Activity Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Positive Regulation Of Nitric Oxide Biosynthetic Process N(omega),N(omega)-dimethyl-L-arginine Catabolic Process	Fructose Metabolic Process Fructose Catabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Pentose-phosphate Shunt
Pathways		Glyoxylate metabolism and glycine degradation Pyrimidine catabolism	Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs		Pyridoxal phosphate Pyruvic acid Glycine Alanine	1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		None	Hereditary fructose intolerance; Fructosemia
GWAS		Metabolite levels ( 21931564 ) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 33031748 ) Symmetrical dimethylarginine levels ( 24159190 25245031 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites ( 21572414 26352407 ) Urinary metabolites (H-NMR features) ( 24586186 )	Age-related cataracts ( 25352737 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514 ) Serum alkaline phosphatase levels ( 29403010 33339817 33547301 )
Interacting Genes		2 interacting genes: ALDOB CYP2E1	22 interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40
Entrez ID		64902	229
HPRD ID		10638	01972
Ensembl ID		ENSG00000113492	ENSG00000136872
Uniprot IDs		Q9BYV1	P05062
PDB IDs		Not available	1QO5 1XDL 1XDM 8D44
GO Terms Enriched among Interactors		Fructose-1-phosphate Aldolase Activity Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Fructose-bisphosphate Aldolase Activity Negative Regulation Of Pentose-phosphate Shunt Small Molecule Biosynthetic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Monocarboxylic Acid Metabolic Process Regulation Of Pentose-phosphate Shunt Lipid Hydroxylation Long-chain Fatty Acid Omega-1 Hydroxylase Activity Monoterpenoid Metabolic Process Fructose Binding Proton-transporting V-type ATPase Complex Assembly Regulation Of NADP Metabolic Process Fructose 1,6-bisphosphate Metabolic Process Arachidonate Epoxygenase Activity Glyceraldehyde-3-phosphate Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Fructose Metabolic Process Epoxygenase P450 Pathway Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Benzene-containing Compound Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Long-chain Fatty Acid Biosynthetic Process ADP Catabolic Process Gluconeogenesis ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Hexose Biosynthetic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Hsp90 Protein Binding Hsp70 Protein Binding Arachidonate Metabolic Process Pyruvate Metabolic Process Cytoskeletal Protein Binding Regulation Of Carbohydrate Catabolic Process Aldehyde Metabolic Process Monooxygenase Activity	Regulation Of Protein Localization To Nucleus Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Chiasma Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Import Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Homeostatic Process Mismatch Repair Complex Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Mesendoderm Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Glycolytic Process Signaling Receptor Activator Activity Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Negative Regulation Of Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Epithelial Cell Proliferation Cellular Response To Stress Apoptotic Process Regulation Of Growth Regulation Of Carbohydrate Catabolic Process Cytosol Mismatched DNA Binding Regulation Of Protein Stability Regulation Of Protein Localization Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Regulation Of ATP Metabolic Process Enzyme Binding Regulation Of MiRNA Transcription Negative Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Reproductive Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Cell Differentiation