AGXT2

Description		alanine--glyoxylate aminotransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Alanine-glyoxylate Transaminase Activity Transaminase Activity Beta-alanine:pyruvate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity
	Biological Process	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Positive Regulation Of Nitric Oxide Biosynthetic Process N(omega),N(omega)-dimethyl-L-arginine Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Pyrimidine catabolism
Drugs		Pyridoxal phosphate Pyruvic acid Glycine Alanine
Diseases
GWAS		Metabolite levels ( 21931564) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Symmetrical dimethylarginine levels ( 24159190 25245031) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		2 interacting genes: ALDOB CYP2E1
Entrez ID		64902
HPRD ID		10638
Ensembl ID		ENSG00000113492
Uniprot IDs		Q9BYV1
PDB IDs
Enriched GO Terms of Interacting Partners?		Fructose-1-phosphate Aldolase Activity Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Fructose-bisphosphate Aldolase Activity Negative Regulation Of Pentose-phosphate Shunt Small Molecule Biosynthetic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Monocarboxylic Acid Metabolic Process Regulation Of Pentose-phosphate Shunt Lipid Hydroxylation Long-chain Fatty Acid Omega-1 Hydroxylase Activity Monoterpenoid Metabolic Process Fructose Binding Proton-transporting V-type ATPase Complex Assembly Regulation Of NADP Metabolic Process Fructose 1,6-bisphosphate Metabolic Process Arachidonate Epoxygenase Activity Glyceraldehyde-3-phosphate Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Fructose Metabolic Process Epoxygenase P450 Pathway Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Benzene-containing Compound Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Long-chain Fatty Acid Biosynthetic Process ADP Catabolic Process Gluconeogenesis ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Hexose Biosynthetic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Hsp90 Protein Binding Hsp70 Protein Binding Arachidonate Metabolic Process Pyruvate Metabolic Process Cytoskeletal Protein Binding Regulation Of Carbohydrate Catabolic Process Aldehyde Metabolic Process Monooxygenase Activity
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