SLC13A3 and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC13A3	CYB5R3
Description		solute carrier family 13 member 3	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Dicarboxylic Acid Transmembrane Transporter Activity Protein Binding Citrate Transmembrane Transporter Activity Alpha-ketoglutarate Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Symporter Activity High-affinity Sodium:dicarboxylate Symporter Activity Solute:sodium Symporter Activity Sodium:dicarboxylate Symporter Activity Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Dicarboxylic Acid Transport Lipid Transport Alpha-ketoglutarate Transport Citrate Transport Glutathione Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Succinate Transmembrane Transport Transport Across Blood-brain Barrier	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways		SLC-mediated transport of organic anions	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Brain volume in infants (white matter) ( 28763065) Chronic kidney disease ( 24351856) Glomerular filtration rate ( 24351856) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mild age-related type 2 diabetes ( 34737425) Serum metabolite levels ( 33031748) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Initial pursuit acceleration ( 29064472)
Interacting Genes		11 interacting genes: ARL13B CISD2 CREB3L1 CYB5R3 ERGIC3 FAM209A GPX8 LEUTX LMNA RMDN3 TSC2	78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15
Entrez ID		64849	1727
HPRD ID		10450	08942
Ensembl ID		ENSG00000158296	ENSG00000100243
Uniprot IDs		B4DF27 Q8WWT9	P00387
PDB IDs		8UVC 8UVD 8UVE 8UVF 8UVG 8UVI	1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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