TNS3 and RBM17

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		TNS3	RBM17
Description		tensin 3	RNA binding motif protein 17
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytosol Focal Adhesion Cell Projection Anchoring Junction	Nucleus Nucleoplasm Spliceosomal Complex Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Hydrolase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Positive Regulation Of Rac Protein Signal Transduction	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		MET interacts with TNS proteins	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Alcohol dependence symptom count ( 29460428) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Basal cell carcinoma ( 33549134 31174203 27539887) Birth weight ( 31043758) Cataracts ( 34127677) Colorectal cancer (diet interaction) ( 24743840) Diastolic blood pressure ( 27841878) Dimensional psychopathology (Positive) ( 29496196) Electroencephalogram traits ( 25387704) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Granulocyte count ( 27863252) Height ( 33713608 31562340) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Insulin-like growth factors ( 21216879) Iris color (a* coordinate) ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer prognosis in former smokers ( 34002017) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pancreatic cancer ( 29422604) Prostate cancer ( 25217961) Pulse pressure ( 30224653 29403010 27841878) QRS duration ( 27659466) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Brooding (response to stress) ( 30886212) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Multiple sclerosis ( 24076602) Soluble interleukin-2 receptor subunit alpha ( 26293465) Vitiligo ( 20410501)
Interacting Genes		12 interacting genes: BCAR1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT MET PTK2 RBM17 SRPK2	33 interacting genes: APBB1 C6orf47 CCDC170 CCHCR1 CEBPA CEP55 CSNK2A1 CWC15 FAM9B GOLGA2 HINFP HSF2BP IQCN LNX2 MIR106B MIR107 MIR128-1 MIR155 MIR21 MIR25 MIRLET7A2 MIRLET7G MIRLET7I OGT PPP1R12C PRC1 QRICH1 RBFOX2 SAP30BP SAT1 SF1 SF3B1 TNS3
Entrez ID		64759	84991
HPRD ID		08438	09501
Ensembl ID		ENSG00000136205	ENSG00000134453
Uniprot IDs		A0A994J537 A0A994J7F3 C9JHU5 E9PCX8 Q68CZ2	Q5W009 Q96I25
PDB IDs			2PE8 2PEH 5LSO 6HIP
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Basal Plasma Membrane Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ATP Binding Positive Regulation Of Cell Population Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Transferase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Apoptotic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphate Metabolic Process Cell Motility Positive Regulation Of Signal Transduction Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Neuron Differentiation Positive Regulation Of Protein Modification Process Growth Factor Binding Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus	RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation Extracellular Vesicle Regulation Of Rac Protein Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Cytokine Production Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Sin3-type Complex Negative Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Necroptotic Process U11/U12 SnRNP Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Lipoprotein Transport Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation
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