RUSF1 and IFNGR1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RUSF1	IFNGR1
Description		RUS family member 1	interferon gamma receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding Cytokine Binding
	Biological Process		Microglial Cell Activation Immune System Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Type III Interferon-mediated Signaling Pathway Astrocyte Activation Defense Response To Virus Type II Interferon-mediated Signaling Pathway Defense Response To Other Organism Cellular Response To Virus Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS			Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		53 interacting genes: AQP6 ARL13B ARL6IP6 BIK C5orf46 CISD2 CMTM5 CREB3 CREB3L1 CREB3L3 DGAT2L6 DHRSX EBP EHHADH ERGIC3 FAM209A FCER1G FFAR2 FKBP7 GJA8 GPR42 HSD17B13 IFNGR1 IL10RA ITGAM LHFPL5 LMNA MMGT1 MS4A4A ODF4 PDCD1LG2 PGRMC2 PSCA PVR RETREG3 RNF5 SCN3B SFXN3 SLC10A1 SLC10A6 SLC30A8 SLC35E3 SLC35H1 SPAG4 SSMEM1 TEX29 TMEM237 TMEM248 TMEM35A TMX2 UBE2I ZCCHC12 ZDHHC15	15 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		64755	3459
HPRD ID		07839	00127
Ensembl ID		ENSG00000140688	ENSG00000027697
Uniprot IDs		Q96GQ5	A0A0S2Z3Y2 A0A2R8Y4U4 A0A2R8YFL3 P15260
PDB IDs			1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Protein Binding Positive Regulation Of Acute Inflammatory Response Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Acetylcholine Receptor Regulator Activity	Type II Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Microglial Cell Activation Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Myeloid Leukocyte Activation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Regulation Of Epithelial Cell Differentiation Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Response To Virus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Macrophage Activation Regulation Of Peptide Hormone Secretion Regulation Of Cell Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Interleukin-23 Production Growth Hormone Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Alpha-beta T Cell Activation Peptide Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Myeloid Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Hormone Secretion Cell Differentiation Positive Regulation Of MHC Class II Biosynthetic Process
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