HEMK1 and ASCL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HEMK1	ASCL3
Description		HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine	achaete-scute family bHLH transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Translational Termination Methylation	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Regulation Of Transcription By RNA Polymerase II Salivary Gland Development Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Epithelium Development Sensory Epithelium Regeneration
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2	7 interacting genes: APP GTF2A1L HEMK1 ID1 MYOD1 TCF3 VPS37C
Entrez ID		51409	56676
HPRD ID		13645	18523
Ensembl ID		ENSG00000114735	ENSG00000176009
Uniprot IDs		A0A140VK98 B2RA37 Q9Y5R4	Q9NQ33
PDB IDs
Enriched GO Terms of Interacting Partners?			Protein Dimerization Activity BHLH Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Euchromatin E-box Binding Cis-regulatory Region Sequence-specific DNA Binding Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Myoblast Fate Determination Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Vitamin D Response Element Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Differentiation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Biosynthetic Process Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of SnRNA Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Tissue Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Transcription Factor TFIIA Complex N-methyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of RNA Biosynthetic Process
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