HEMK1 and SHOX

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HEMK1	SHOX
Name		HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine	SHOX homeobox
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Translational Termination Methylation	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Diseases		None	SHOX-related haploinsufficiency disorders, including: Isolated short stature; Langer syndrome; Leri-Weill syndrome
GWAS		Appendicular lean mass ( 33097823 ) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025 ) Cocaine dependence ( 31212010 ) Depressive symptom (appetite changes) (binary trait) ( 31530331 ) Depressive symptoms (binary sum-score) ( 31530331 ) Depressive symptoms (sum-score) ( 31530331 ) Height ( 28552196 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2	5 interacting genes: CSNK2A1 GLIS2 HEMK1 IGBP1 NKX2-5
Entrez ID		51409	6473
HPRD ID		13645	02430
Ensembl ID		ENSG00000114735	ENSG00000185960
Uniprot IDs		A0A140VK98 B2RA37 Q9Y5R4	O15266
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development N-methyltransferase Activity Positive Regulation Of Aggrephagy Negative Regulation Of Biosynthetic Process Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Involved In Heart Morphogenesis Atrioventricular Node Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Membraneless Organelle Assembly Atrial Septum Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Metabolic Process Ventricular Cardiac Muscle Cell Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Wnt Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Muscle Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Adult Heart Development Heart Trabecula Formation Ventricular Trabecula Myocardium Morphogenesis