MRPS25 and NUAK1

Data Source: HiPPIP (Novel)

		MRPS25	NUAK1
Name		mitochondrial ribosomal protein S25	NUAK family kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Structural Constituent Of Ribosome	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitochondrial Translation	Protein Phosphorylation DNA Damage Response Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Regulation of TP53 Activity through Phosphorylation
Drugs		None	Fostamatinib
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 )	Alzheimer's disease biomarkers ( 23419831 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) Brain morphology (MOSTest) ( 32665545 ) General glucose level in pregnancy (gestational week 30-32) ( 30324795 ) Lateral ventricular volume in normal aging ( 30258056 ) Medial thalamic nuclei volume ( 34006833 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795 )
Novel Interactors		7 novel interactors: CAND2 COLQ FBLN2 HDAC11 MKRN2 NUAK1 XPC	2 novel interactors: MARK2 MRPS25
Interacting Genes		2 interacting genes: ERCC6 UBC	5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC
Entrez ID		64432	9891
HPRD ID		17594	12171
Ensembl ID		ENSG00000131368	ENSG00000074590
Uniprot IDs		P82663	O60285
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	Not available
GO Terms Enriched among Interactors		Pyrimidine Dimer Repair Response To UV-B Site Of DNA Damage Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleotide-excision Repair Heteroduplex DNA Loop Binding Nucleotide-excision Repair Factor 2 Complex Post-translational Protein Modification Protein Modification Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein DNA Damage Checkpoint Signaling Acetylcholine Catabolic Process In Synaptic Cleft SCF Complex Assembly Extracellular Matrix Structural Constituent XPC Complex Acetylcholine Catabolic Process DNA Damage Sensor Activity Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To UV Signal Transduction In Response To DNA Damage Response To Superoxide Nucleotide-excision Repair Complex DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Bubble DNA Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Extracellular Matrix Constituent Conferring Elasticity Regulation Of Synaptic Assembly At Neuromuscular Junction Histone Deacetylase Activity, Hydrolytic Mechanism Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair UV-damage Excision Repair Negative Regulation Of Cell Cycle Phase Transition	Protein Metabolic Process Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Postsynapse Macromolecule Metabolic Process Nuclear Chromosome Segregation Sister Chromatid Segregation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Component Organization PTB Domain Binding Regulation Of Synapse Assembly Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Staurosporine Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Microtubule Organizing Center Chromosome Segregation Inner Cell Mass Cell Fate Commitment