MRPS25 and COLQ

		MRPS25	COLQ
Description		mitochondrial ribosomal protein S25	collagen like tail subunit of asymmetric acetylcholinesterase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Collagen Trimer Basement Membrane Extracellular Space Plasma Membrane Cell Junction Extracellular Matrix Neuromuscular Junction Synaptic Cleft Synapse
	Molecular Function	Structural Constituent Of Ribosome	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding
	Biological Process	Mitochondrial Translation	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Synaptic Assembly At Neuromuscular Junction Skeletal Muscle Acetylcholine-gated Channel Clustering Establishment Of Protein Localization To Membrane
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases			Congenital myasthenic syndrome
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Diverticular disease ( 28585551 30177863) Diverticulitis ( 28585551)
Interacting Genes		2 interacting genes: ERCC6 UBC	5 interacting genes: ACHE BCHE MUSK SGTB SNCA
Entrez ID		64432	8292
HPRD ID		17594	04328
Ensembl ID		ENSG00000131368	ENSG00000206561
Uniprot IDs		P82663	Q9Y215
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	1VZJ
Enriched GO Terms of Interacting Partners?		Pyrimidine Dimer Repair Response To UV-B Site Of DNA Damage Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleotide-excision Repair Heteroduplex DNA Loop Binding Nucleotide-excision Repair Factor 2 Complex Post-translational Protein Modification Protein Modification Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein DNA Damage Checkpoint Signaling Acetylcholine Catabolic Process In Synaptic Cleft SCF Complex Assembly Extracellular Matrix Structural Constituent XPC Complex Acetylcholine Catabolic Process DNA Damage Sensor Activity Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To UV Signal Transduction In Response To DNA Damage Response To Superoxide Nucleotide-excision Repair Complex DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Bubble DNA Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Extracellular Matrix Constituent Conferring Elasticity Regulation Of Synaptic Assembly At Neuromuscular Junction Histone Deacetylase Activity, Hydrolytic Mechanism Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair UV-damage Excision Repair Negative Regulation Of Cell Cycle Phase Transition	Acetylcholine Catabolic Process Acetylcholinesterase Activity Cholinesterase Activity Regulation Of Receptor Recycling Carboxylic Ester Hydrolase Activity Negative Regulation Of Synaptic Transmission Synapse Organization Hsp70 Protein Binding Negative Regulation Of Synaptic Transmission, Cholinergic Receptor Internalization Neuromuscular Junction Cocaine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Amyloid-beta Binding Response To Alkaloid Modulation Of Chemical Synaptic Transmission Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process TRC Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Identical Protein Binding Choline Binding Regulation Of Synapse Assembly Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Receptor-mediated Endocytosis Ribosome Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Serine Hydrolase Activity Choline Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Neuroblast Differentiation Response To Iron(II) Ion Acetylcholine Binding Synapse Alkaloid Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial ATP Synthesis Coupled Electron Transport
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