WIPF3 and WASL

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		WIPF3	WASL
Description		WAS/WASL interacting protein family member 3	WASP like actin nucleation promoting factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Recycling Endosome WASH Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding	Actin Binding Protein Binding GTPase Regulator Activity
	Biological Process	Exocytosis Spermatogenesis Cell Differentiation Endocytic Recycling Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi	Vesicle Budding From Membrane Actin Filament Organization Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Actin Cytoskeleton Organization Actin Filament Polymerization Vesicle Transport Along Actin Filament Protein-containing Complex Localization Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Dendritic Spine Morphogenesis Protein-containing Complex Assembly Regulation Of Postsynapse Organization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Corneal curvature ( 22969067) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Heel bone mineral density ( 30598549) Microalbuminuria ( 31511532) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Platelet count ( 22139419 27863252) Plateletcrit ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		2 interacting genes: VSTM2L WASL	62 interacting genes: ABI2 ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 ARPC4 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITCH ITGB1BP2 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD OSTF1 PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOQ RIPPLY3 RNF8 RPL7AP66 SDCBP SH3GL3 SH3RF1 SNX9 SORBS2 SRC TNNT3 TRIP10 UBASH3A UBASH3B VASP VIPR1 WIPF1 WIPF2 WIPF3 WWP1 ZNF395
Entrez ID		644150	8976
HPRD ID		18947	05448
Ensembl ID		ENSG00000122574	ENSG00000106299
Uniprot IDs		A0A0A0MSG0 A6NGB9	O00401
PDB IDs			2FF3 2LNH 2VCP 4CC2 4CC7 9DLX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Vesicle Transport Along Actin Filament Negative Regulation Of Lymphocyte Migration Regulation Of Plasma Membrane Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Actin Filament Polymerization GTPase Regulator Activity Vesicle Budding From Membrane Positive Regulation Of Filopodium Assembly Dendritic Spine Organization Negative Regulation Of Mononuclear Cell Migration Neuron Projection Organization Regulation Of Filopodium Assembly Postsynapse Organization Vesicle Cytoskeletal Trafficking Negative Regulation Of Leukocyte Migration Actin Polymerization Or Depolymerization Positive Regulation Of Receptor-mediated Endocytosis Spindle Localization Actin Filament-based Movement Regulation Of Lymphocyte Migration Protein-containing Complex Localization Endocytic Vesicle Membrane Protein Polymerization	Endocytosis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Actin Filament Polymerization Import Into Cell Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Cytoplasm Cytosol Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Profilin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Actin Filament-based Process Positive Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Endocytosis Positive Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport Regulation Of Cell Projection Organization Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Cellular Component Size Cytoskeletal Anchor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Focal Adhesion Regulation Of Cell Projection Assembly Cytoskeleton Plasma Membrane Tubulation Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Organization Proline-rich Region Binding Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome SH3 Domain Binding Regulation Of Vesicle-mediated Transport Actin Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
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