IKZF5 and IKZF2

Number of citations of the paper that reports this interaction (PMID 10978333)
15

Data Source:
HPRD (in vitro)

		IKZF5	IKZF2
Gene Name		IKAROS family zinc finger 5 (Pegasus)	IKAROS family zinc finger 2 (Helios)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Metal Ion Binding	Molecular_function DNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Biological_process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Eosinophil counts ( 19198610)
Protein-Protein Interactions		6 interactors: CCDC85B IKZF1 IKZF2 IKZF3 IKZF4 LDOC1	9 interactors: AQP1 CTBP1 CTBP2 HDAC4 HOXA1 IKZF1 IKZF4 IKZF5 LONRF1
Entrez ID		64376	22807
HPRD ID		05873	05872
Ensembl ID		ENSG00000095574	ENSG00000030419
Uniprot IDs		Q9H5V7	B4DWF2 Q9UKS7
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Neutrophil Differentiation Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Mesoderm Development Regulation Of Lymphocyte Differentiation B Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NK T Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Granulocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Lymphocyte Activation Lymph Node Development Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Peyer's Patch Development Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Natural Killer Cell Differentiation Regulation Of Cell Activation Leukocyte Activation Regulation Of B Cell Differentiation Regulation Of Growth Negative Regulation Of Cellular Metabolic Process Cell Activation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Multicellular Organism Growth	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter White Fat Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Viral Genome Replication Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Retinoic Acid Regulation Of Gene Expression Positive Regulation Of Neutrophil Differentiation Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process B Cell Differentiation Facial Nucleus Development Carbon Dioxide Transmembrane Transport Corticotropin Secretion Establishment Or Maintenance Of Actin Cytoskeleton Polarity
Tagcloud ?			aggressive aiolos alterations aneuploidy chromosomes commonly differ encoding exome explored haploid harbor helios hypodiploid ikzf3 leukemic lymphoblastic lymphoid near nontumor phosphoinositide pi3k profiles profiling ras rb1 submicroscopic subtype tp53
Tagcloud (Difference) ?			aggressive aiolos alterations aneuploidy chromosomes commonly differ encoding exome explored haploid harbor helios hypodiploid ikzf3 leukemic lymphoblastic lymphoid near nontumor phosphoinositide pi3k profiles profiling ras rb1 submicroscopic subtype tp53
Tagcloud (Intersection) ?