RFK and DNAJB9

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RFK	DNAJB9
Gene Name		riboflavin kinase	DnaJ (Hsp40) homolog, subfamily B, member 9
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Riboflavin Kinase Activity Metal Ion Binding	Protein Binding Misfolded Protein Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Apoptotic Process Riboflavin Biosynthetic Process FMN Biosynthetic Process Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs		Riboflavin Riboflavin Monophosphate Adenosine-5\'-Diphosphate
Diseases
GWAS		Multiple sclerosis (age of onset) ( 19010793)	Smoking behavior ( 22006218)
Protein-Protein Interactions		2 interactors: DNAJB9 RAB1A	10 interactors: DYNLL1 FAM71C FSCN1 KIAA0368 MYL6 PLK1 RFK SLC16A8 TCEA2 TCERG1
Entrez ID		55312	4189
HPRD ID		17969	07047
Ensembl ID		ENSG00000135002	ENSG00000128590
Uniprot IDs		B2RDZ2 Q969G6	Q6FIF1 Q9UBS3
PDB IDs		1NB0 1NB9 1P4M 1Q9S	2CTR
Enriched GO Terms of Interacting Partners?		Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Interleukin-8 Production Cargo Loading Into Vesicle Growth Hormone Secretion Positive Regulation Of Glycoprotein Metabolic Process COPII-coated Vesicle Budding Virion Assembly Positive Regulation Of Protein Metabolic Process Cytokine Secretion Vesicle Transport Along Microtubule Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization ER-associated Ubiquitin-dependent Protein Catabolic Process Localization Within Membrane Melanosome Localization Autophagic Vacuole Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Organelle Transport Along Microtubule Macroautophagy Rab Protein Signal Transduction Cellular Pigmentation Peptide Hormone Secretion Peptide Secretion Catabolic Process Golgi Organization Membrane Budding Hormone Secretion Endoplasmic Reticulum Unfolded Protein Response Hormone Transport Peptide Transport Cellular Response To Unfolded Protein ER To Golgi Vesicle-mediated Transport Regulation Of Protein Metabolic Process Vacuole Organization ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Pigmentation Protein Secretion Amide Transport Response To Unfolded Protein Microtubule-based Transport Cytokine Production Cellular Response To Starvation Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cellular Metabolic Process	Riboflavin Biosynthetic Process FMN Biosynthetic Process Activation Of APC-Cdc20 Complex Activity G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of NAD(P)H Oxidase Activity
Tagcloud ?		alter analytical associations biologically depressive electrophoretic example genomics goal grk5 gwa insights joining mobility plausible reached relevance remission reuptake riboflavin rs11144870 rs915120 serotonin shift snp snps ssri ssris wide	applicable attractor bcam biomarker bionetworks calculating called cd68 consideration cxcl12 dream existing facility fgd3 hormonal lym mes metagene metagenes outperform predictions remarkable sage selector suggestion susd3 unexpected universally winning
Tagcloud (Difference) ?		alter analytical associations biologically depressive electrophoretic example genomics goal grk5 gwa insights joining mobility plausible reached relevance remission reuptake riboflavin rs11144870 rs915120 serotonin shift snp snps ssri ssris wide	applicable attractor bcam biomarker bionetworks calculating called cd68 consideration cxcl12 dream existing facility fgd3 hormonal lym mes metagene metagenes outperform predictions remarkable sage selector suggestion susd3 unexpected universally winning
Tagcloud (Intersection) ?