TMEM253 and TUBA1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMEM253	TUBA1B
Gene Name		transmembrane protein 253	tubulin, alpha 1b
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Microtubule Cytoplasmic Microtubule Extracellular Vesicular Exosome
	Molecular Function		Double-stranded RNA Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process		Microtubule Cytoskeleton Organization Protein Folding Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division Cellular Response To Interleukin-4
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		2 interactors: RAPGEF5 TUBA1B	27 interactors: A2M AGTRAP CCT2 EPN2 ESR1 FYN GRM7 GZMM HDAC6 MAPT MINK1 MTCL1 MYC NFKBIA PFDN5 PIK3R1 PSEN1 PTP4A1 PXN SIAH1 SLX1B SMAD2 SNAP91 TERT TMEM253 TOM1L1 TUBG1
Entrez ID		643382	10376
HPRD ID			03960
Ensembl ID		ENSG00000232070	ENSG00000123416
Uniprot IDs		P0C7T8	P68363
PDB IDs			2E4H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Growth Factor T Cell Receptor Signaling Pathway Negative Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Catalytic Activity Response To Stress Regulation Of Cell Death Negative Regulation Of Signaling Cellular Protein Complex Assembly Cellular Response To Growth Factor Stimulus Cell Communication Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Stimulus Cellular Response To Stimulus Response To DsRNA Programmed Cell Death Regulation Of Metabolic Process Tube Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Death Death Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Regulation Of Microtubule-based Movement Regulation Of Cell Morphogenesis Developmental Process Cellular Response To Stress Regulation Of Cell Differentiation Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Transport Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Organelle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Receptor Activity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Signal Transduction Negative Regulation Of Programmed Cell Death Growth Hormone Receptor Signaling Pathway
Tagcloud ?			accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated e2f1 exceptions explorative exploratory gepat hallmark hodgkin implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon
Tagcloud (Difference) ?			accounts annotation aurora bad bub1 cdc2 cdc25 cebpb cgh compact correlating delineated e2f1 exceptions explorative exploratory gepat hallmark hodgkin implicates incurable mantle mcl proliferative refine socs1 tight wee1 wilcoxon
Tagcloud (Intersection) ?