TMEM253 and RAPGEF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMEM253	RAPGEF5
Gene Name		transmembrane protein 253	Rap guanine nucleotide exchange factor (GEF) 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Nucleus
	Molecular Function		Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process		Small GTPase Mediated Signal Transduction Nervous System Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity
Pathways
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Thyroid stimulating hormone ( 17903292)
Protein-Protein Interactions		2 interactors: RAPGEF5 TUBA1B	7 interactors: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		643382	9771
HPRD ID			15208
Ensembl ID		ENSG00000232070	ENSG00000136237
Uniprot IDs		P0C7T8	A8MQ07 Q5JPD2 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction	Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Platelet Activation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Vasculogenesis Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Blood Coagulation Hemostasis Microvillus Assembly Negative Regulation Of Synaptic Vesicle Exocytosis Microvillus Organization Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Regulation Of Cell Projection Organization Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Differentiation Regulation Of Rap Protein Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Establishment Of Endothelial Barrier Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Exocytosis Actin Filament-based Process Regulation Of Locomotion Cell Activation
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