NFKBIZ and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NFKBIZ	NFKB2
Description		NFKB inhibitor zeta	nuclear factor kappa B subunit 2
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GO Annotations	Cellular Component	Nucleus Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Protein Binding POU Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Lymphocyte Activation Involved In Immune Response Plasma Cell Differentiation T Cell Mediated Immunity Chronic Inflammatory Response Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Inflammatory Response Response To Xenobiotic Stimulus Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Keratinocyte Differentiation T Cell Differentiation Positive Regulation Of Defense Response Response To Lipopolysaccharide Keratinocyte Activation Response To Cytokine B Cell Proliferation MRNA Transcription By RNA Polymerase II Skin Development Keratinocyte Proliferation T-helper 1 Cell Differentiation Isotype Switching Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Inflammatory Response Regulation Of Immune Response Defense Response To Gram-negative Bacterium T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Response To Folic Acid Establishment Of Skin Barrier Transcription Preinitiation Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus T-helper 17 Cell Differentiation Response To Cisplatin Inflammatory Response To Wounding Execution Phase Of Apoptosis Cellular Response To Interleukin-17 Skin Epidermis Development Response To Gram-positive Bacterium Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of T-helper 17 Cell Differentiation	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction Extracellular Matrix Organization Response To Lipopolysaccharide Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Intracellular Signaling Cassette
Pathways			RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection Regulation of PD-L1(CD274) transcription
Drugs			Sulfasalazine Donepezil Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Multiple sclerosis ( 21833088) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Spatial memory ( 31596458) Ulcerative colitis ( 26192919)	Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: NFKB1 NFKB2 STAT3	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		64332	4791
HPRD ID		09217	01239
Ensembl ID		ENSG00000144802	ENSG00000077150
Uniprot IDs		Q9BYH8	Q00653
PDB IDs		9BOR	1A3Q 2D96 3DO7 4OT9 5ZMC 7CLI 7VUP 7VUQ 7W7L 8G8Q 8G8S
Enriched GO Terms of Interacting Partners?		I-kappaB/NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Interleukin-17 Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Peptide Response To Cytokine Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of MiRNA Metabolic Process Response To Lipid Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Intracellular Signaling Cassette Negative Regulation Of Small Molecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Immune Response NF-kappaB P50/p65 Complex Chromatin Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bcl3/NF-kappaB2 Complex Follicular Dendritic Cell Differentiation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hyaluronan Biosynthetic Process Follicular Dendritic Cell Activation Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Transcription Regulator Complex Negative Regulation Of Vitamin D Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Sequestering Activity Response To Lipopolysaccharide Mammary Gland Involution Gene Expression Positive Regulation Of RNA Biosynthetic Process Response To Peptide Hormone Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of Defense Response Adaptive Immune Response Postsynapse To Nucleus Signaling Pathway T-helper 17 Type Immune Response Negative Regulation Of Hydrogen Peroxide Metabolic Process	Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Negative Regulation Of Biosynthetic Process Cytoplasm Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleoplasm Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Defense Response NF-kappaB Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process
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