NFKBIZ

Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	Transcription Cofactor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Inflammatory Response
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-protein Interactions		3 interactors: NFKB1 NFKB2 STAT3
Entrez ID		64332
HPRD ID		09217
Ensembl ID		ENSG00000144802
Uniprot IDs		Q9BYH8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Interleukin-6 Response To Interleukin-6 Inflammatory Response NIK/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Response To Cytokine Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription, DNA-templated Defense Response Negative Regulation Of Biosynthetic Process Follicular Dendritic Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Neurotrophin Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		bowel cd chemokine chemotaxis colitis consequences crohn cultured cxcl1 cxcl6 discovered elisa fibroblast fibroblasts ibd il ileum intestinal microarray neutrophil performing proinflammatory prominent qrt responsive uc ulcerative upregulated validated