NFKBIZ

Description		NFKB inhibitor zeta
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GO Annotations	Cellular Component	Nucleus Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Protein Binding POU Domain Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Lymphocyte Activation Involved In Immune Response Plasma Cell Differentiation T Cell Mediated Immunity Chronic Inflammatory Response Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Inflammatory Response Response To Xenobiotic Stimulus Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Keratinocyte Differentiation T Cell Differentiation Positive Regulation Of Defense Response Response To Lipopolysaccharide Keratinocyte Activation Response To Cytokine B Cell Proliferation MRNA Transcription By RNA Polymerase II Skin Development Keratinocyte Proliferation T-helper 1 Cell Differentiation Isotype Switching Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Inflammatory Response Regulation Of Immune Response Defense Response To Gram-negative Bacterium T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Response To Folic Acid Establishment Of Skin Barrier Transcription Preinitiation Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus T-helper 17 Cell Differentiation Response To Cisplatin Inflammatory Response To Wounding Execution Phase Of Apoptosis Cellular Response To Interleukin-17 Skin Epidermis Development Response To Gram-positive Bacterium Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of T-helper 17 Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Spatial memory ( 31596458) Ulcerative colitis ( 26192919)
Interacting Genes		3 interacting genes: NFKB1 NFKB2 STAT3
Entrez ID		64332
HPRD ID		09217
Ensembl ID		ENSG00000144802
Uniprot IDs		Q9BYH8
PDB IDs		9BOR
Enriched GO Terms of Interacting Partners?		I-kappaB/NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Interleukin-17 Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Peptide Response To Cytokine Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of MiRNA Metabolic Process Response To Lipid Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Intracellular Signaling Cassette Negative Regulation Of Small Molecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Immune Response NF-kappaB P50/p65 Complex Chromatin Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bcl3/NF-kappaB2 Complex Follicular Dendritic Cell Differentiation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hyaluronan Biosynthetic Process Follicular Dendritic Cell Activation Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Transcription Regulator Complex Negative Regulation Of Vitamin D Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Sequestering Activity Response To Lipopolysaccharide Mammary Gland Involution Gene Expression Positive Regulation Of RNA Biosynthetic Process Response To Peptide Hormone Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of Defense Response Adaptive Immune Response Postsynapse To Nucleus Signaling Pathway T-helper 17 Type Immune Response Negative Regulation Of Hydrogen Peroxide Metabolic Process
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