ABCG5 and ABCG8

Number of citations of the paper that reports this interaction (PMID 12208867)
61

Data Source:
HPRD (in vivo)

		ABCG5	ABCG8
Gene Name		ATP-binding cassette, sub-family G (WHITE), member 5	ATP-binding cassette, sub-family G (WHITE), member 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Heterodimerization Activity	Protein Binding ATP Binding ATPase Activity Cholesterol Transporter Activity Protein Heterodimerization Activity
	Biological Process	Response To Nutrient Excretion Response To Ionizing Radiation Negative Regulation Of Intestinal Phytosterol Absorption Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Small Molecule Metabolic Process Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Small Molecule Metabolic Process Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport
Pathways		Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Lipid digestion, mobilization, and transport Trafficking of dietary sterols ABCA transporters in lipid homeostasis	Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Lipid digestion, mobilization, and transport Trafficking of dietary sterols ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 19060911 20686565) Lipid metabolism phenotypes ( 19936222)	Cholesterol, total ( 20686565) Gallstones ( 17632509) LDL cholesterol ( 23726366 19060906 20686565) Lipid metabolism phenotypes ( 19936222) Phytosterol levels ( 20529992)
Protein-Protein Interactions		1 interactors: ABCG8	8 interactors: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1
Entrez ID		64240	64241
HPRD ID		05678	05679
Ensembl ID		ENSG00000138075	ENSG00000143921
Uniprot IDs		Q9H222	Q9H221
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Cholesterol Transport Lipid Digestion Intestinal Absorption Negative Regulation Of Lipid Transport Cholesterol Efflux Regulation Of Cholesterol Transport Excretion Sterol Transport Cholesterol Transport Cholesterol Homeostasis Sterol Homeostasis Phospholipid Transport Regulation Of Lipid Transport Lipid Homeostasis Digestion Response To Nutrient Lipid Transport Lipid Localization Negative Regulation Of Transport Response To Nutrient Levels Organic Anion Transport Response To Extracellular Stimulus Response To Drug Anion Transport	Negative Regulation Of Lipid Transport Apoptotic Process Programmed Cell Death Cell Death Skeletal Muscle Cell Differentiation Death Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Lipid Transport Neutral Lipid Metabolic Process Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Tissue Development Positive Regulation Of Epithelial Cell Proliferation Diacylglycerol Biosynthetic Process Activation Of Ral GTPase Activity Activation Of Phospholipase A2 Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Response To Hormone Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Gonad Development Regulation Of Protein Metabolic Process Development Of Primary Sexual Characteristics Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Translation Muscle Organ Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Sex Differentiation Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Cholesterol Transport Positive Regulation Of Fatty Acid Beta-oxidation CDP-diacylglycerol Biosynthetic Process Positive Regulation Of Vesicle Fusion Regulation Of Phospholipase A2 Activity Striated Muscle Tissue Development Positive Regulation Of Cellular Metabolic Process Regulation Of Female Gonad Development CDP-diacylglycerol Metabolic Process Lipid Digestion Positive Regulation Of Protein Transport Angiogenesis
Tagcloud ?		abca1 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	abca1 abcg5 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4