ABCG5

Description		ATP binding cassette subfamily G member 5
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex Apical Part Of Cell
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity
	Biological Process	Lipid Transport Response To Nutrient Response To Xenobiotic Stimulus Response To Ionizing Radiation Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Sterol Transport Intestinal Cholesterol Absorption Response To Nutrient Levels Cholesterol Efflux Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases		Sitosterolemia
GWAS		C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) LDL cholesterol ( 19060911 20686565 24097068) Lipid metabolism phenotypes ( 19936222)
Interacting Genes		1 interacting genes: ABCG8
Entrez ID		64240
HPRD ID		05678
Ensembl ID		ENSG00000138075
Uniprot IDs		Q9H222
PDB IDs		5DO7 7JR7 7R87 7R88 7R89 7R8A 7R8B 8CUB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Regulation Of Intestinal Cholesterol Absorption Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption Cholesterol Efflux Cholesterol Transfer Activity ATPase-coupled Transmembrane Transporter Activity Intestinal Absorption Response To Muscle Activity Acylglycerol Homeostasis Triglyceride Homeostasis ABC-type Transporter Activity Cholesterol Transport Response To Activity Sterol Transport Digestive System Process Phospholipid Transport Sterol Homeostasis Cholesterol Homeostasis Organophosphate Ester Transport Response To Nutrient Organic Hydroxy Compound Transport Lipid Homeostasis Protein Dimerization Activity Receptor Complex Response To Xenobiotic Stimulus Lipid Transport Protein Heterodimerization Activity ATP Hydrolysis Activity Apical Plasma Membrane Response To Nutrient Levels
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