DPEP2 and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		DPEP2	NLGN3
Description		dipeptidase 2	neuroligin 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Side Of Membrane	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Peptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Metal Ion Binding Metallodipeptidase Activity	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Leukotriene D4 Catabolic Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels in current drinkers ( 30698716)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		1 interacting genes: NLGN3	65 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		64174	54413
HPRD ID		07011	02275
Ensembl ID		ENSG00000167261	ENSG00000196338
Uniprot IDs		Q9H4A9	A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs			8GS3
Enriched GO Terms of Interacting Partners?		Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Presynapse Organization Vocalization Behavior Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Axon Extension Modulation Of Excitatory Postsynaptic Potential Social Behavior Membrane Assembly Positive Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Endocytic Vesicle Scaffold Protein Binding Neuron Projection Extension Vesicle-mediated Transport In Synapse Cell Adhesion Molecule Binding Synapse Assembly Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Cell Junction Assembly Developmental Cell Growth Regulation Of Nervous System Process Developmental Growth Involved In Morphogenesis Positive Regulation Of Synaptic Transmission Adult Behavior Learning Regulation Of Synapse Assembly Receptor-mediated Endocytosis Presynapse Postsynaptic Membrane Learning Or Memory Regulation Of Cell Junction Assembly	Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process
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