NPAS3 and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		NPAS3	TMEM132D
Description		neuronal PAS domain protein 3	transmembrane protein 132D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Arterial stiffness index ( 31235810) Bipolar disorder ( 31043756) Body mass index ( 26426971 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Coffee consumption ( 31046077) Colorectal or endometrial cancer ( 26621817) Diisocyanate-induced asthma ( 25918132) Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Inflammatory biomarkers ( 22228203) Intraocular pressure ( 29617998) Lean body mass ( 28552196) Metabolite levels ( 23823483) Mitochondrial DNA levels ( 25240745) Moderate-to-late spontaneous preterm birth ( 31194736) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Night sleep phenotypes ( 27126917) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) QRS duration in Tripanosoma cruzi seropositivity ( 24324551) Schizophrenia ( 28991256) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Serum immune biomarker levels ( 32066700) Smoking status (current vs never) ( 33082346) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730) Walking pace ( 33128006)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		2 interacting genes: CHRM5 TMEM132D	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		64067	121256
HPRD ID		11400	13906
Ensembl ID		ENSG00000151322	ENSG00000151952
Uniprot IDs		Q8IXF0 X5D2Q4 X5D7M0 X5D988	Q14C87
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation Actin Modification Striated Muscle Myosin Thick Filament Cytosolic Ciliogenesis Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Free Ubiquitin Chain Polymerization Tat Protein Binding Regulation Of Dephosphorylation Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Transmission Of Nerve Impulse Dopamine Transport Muscle Cell Cellular Homeostasis Negative Regulation Of Cilium Assembly Positive Regulation Of Autophagosome Assembly Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Translation Initiation Factor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Myosin Binding Negative Regulation Of Toll-like Receptor 4 Signaling Pathway	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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