SDF2 and CCL8

		SDF2	CCL8
Description		stromal cell derived factor 2	C-C motif chemokine ligand 8
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Protein Folding Chaperone Complex	Extracellular Region Extracellular Space
	Molecular Function	Misfolded Protein Binding	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	Protein Refolding	Positive Regulation Of Leukocyte Migration Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Myoblast Differentiation Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Myoblast Fusion
Pathways
Drugs		Malonate Ion	Pidolic acid
Diseases
GWAS			Blood protein levels ( 30072576) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		3 interacting genes: HNRNPD HSPB2 UBC	20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2
Entrez ID		6388	6355
HPRD ID		04243	03791
Ensembl ID		ENSG00000132581	ENSG00000108700
Uniprot IDs		Q6IBU4 Q99470	P80075
PDB IDs			1ESR 7S59 7S5A
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Eosinophil Migration Eosinophil Chemotaxis Cell Chemotaxis Cytokine Activity Chemoattractant Activity Humoral Immune Response Positive Chemotaxis Chemotaxis Locomotion Hepatocyte Dedifferentiation Cellular Response To Putrescine Granulocyte Chemotaxis Cytokine-mediated Signaling Pathway Granulocyte Migration Circadian Regulation Of Translation Inflammatory Response Positive Regulation Of Cell Migration Myeloid Leukocyte Migration Positive Regulation Of Cell Motility Leukocyte Chemotaxis Positive Regulation Of Locomotion Cell-cell Signaling Signaling Extracellular Space Somatic Muscle Development Cell Communication Heparin Binding Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex Response To Rapamycin Cell Dedifferentiation Intracellular Calcium Ion Homeostasis Defense Response To Symbiont Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Calcium Ion Homeostasis Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Leukocyte Migration Cell Migration CRD-mediated MRNA Stabilization Phospholipase Activator Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Host-mediated Suppression Of Viral Genome Replication Regulation Of Cell Migration	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Cell Migration Inflammatory Response Leukocyte Chemotaxis Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Leukocyte Migration Antimicrobial Humoral Response Immune Response Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Cytokine Activity Defense Response Humoral Immune Response Immune System Process Granulocyte Chemotaxis Granulocyte Migration C-C Chemokine Binding Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Extracellular Space Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Response To Stress Response To Other Organism Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Calcium-mediated Signaling Response To Lipopolysaccharide Regulation Of Cell Migration
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