CCL4 and PRRG2

		CCL4	PRRG2
Description		C-C motif chemokine ligand 4	proline rich and Gla domain 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Cell Migration Host-mediated Suppression Of Viral Transcription Eosinophil Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Chemotaxis	Proteolysis Blood Coagulation
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 33536631) Red blood cell count ( 27863252 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		26 interacting genes: ACKR2 ARL13B CCL3 CCR1 CCR3 CCR5 CCR8 CNR2 CXCL8 GJA8 GPR152 GPRC5D MARCHF2 MRM1 SLC10A6 SLC18A1 SLC30A2 SLC30A8 SLC7A1 TAS2R5 TIMMDC1 TMEM14B TMEM179B TMEM31 TMEM86B UNC93A	8 interacting genes: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1
Entrez ID		6351	5639
HPRD ID		01657	09189
Ensembl ID		ENSG00000275302	ENSG00000126460
Uniprot IDs		P13236	O14669 Q8TAS3
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL	9BVP 9BVQ
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Chemokine-mediated Signaling Pathway Locomotion G Protein-coupled Receptor Activity Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway Membrane Plasma Membrane Chemokine (C-C Motif) Ligand 5 Binding Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Immune Response Inflammatory Response Response To Cytokine Response To Peptide Zinc:proton Antiporter Activity Cell Motility Leukocyte Migration Cytokine-mediated Signaling Pathway Intracellular Signaling Cassette Cellular Response To Cytokine Stimulus Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Zinc Ion Import Into Organelle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Monoatomic Cation Transport Defense Response External Side Of Plasma Membrane Sarcoplasmic Reticulum Calcium Ion Transport Dendritic Cell Chemotaxis Metal Ion Transport Transmembrane Transport Response To Interleukin-1 Monoatomic Cation Transmembrane Transporter Activity Import Into Cell Negative Regulation Of Bone Mineralization Positive Regulation Of Leukocyte Chemotaxis Immune System Process Monoatomic Ion Transport Positive Regulation Of Neuroinflammatory Response Secretory Granule Membrane Monocyte Chemotaxis Zinc Ion Transmembrane Transporter Activity Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity	Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
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