SCN1B and ANK3

Number of citations of the paper that reports this interaction (PMID 11997395)
30

Data Source:
HPRD (in vivo, in vitro)

		SCN1B	ANK3
Gene Name		sodium channel, voltage gated, type I beta subunit	ankyrin 3, node of Ranvier (ankyrin G)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Extracellular Region Intercalated Disc T-tubule Node Of Ranvier	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Dendrite Neuromuscular Junction Node Of Ranvier Paranode Region Of Axon Sarcolemma Costamere Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding Cadherin Binding
	Biological Process	Cell Adhesion Synaptic Transmission Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Serum albumin level ( 23022100)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 22182935 21926972 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Schizophrenia ( 20185149)
Protein-Protein Interactions		3 interactors: ANK3 NFASC SCN2B	12 interactors: FADD FAS HOOK1 KCNC1 MAPK6 PIK3R1 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4
Entrez ID		6324	288
HPRD ID		02581	02715
Ensembl ID		ENSG00000105711	ENSG00000151150
Uniprot IDs		B4DI92 Q07699	Q12955 Q8NAK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Transmission Of Nerve Impulse Regulation Of Sodium Ion Transport Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Homeostasis Synapse Organization Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Regulation Of Membrane Potential Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Response To Pyrethroid Regulation Of Membrane Depolarization During Action Potential Axon Guidance Clustering Of Voltage-gated Sodium Channels Regulation Of Cardiac Muscle Cell Action Potential Nervous System Development Regulation Of Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Neuronal Ion Channel Clustering Protein Localization To Paranode Region Of Axon Cytoskeletal Anchoring At Plasma Membrane Protein Localization To Juxtaparanode Region Of Axon Axonogenesis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Axon Development Negative Regulation Of Potassium Ion Transmembrane Transport Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Magnesium Ion Homeostasis Paranodal Junction Assembly Neuron Projection Morphogenesis Response To Insecticide Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Cell Morphogenesis Involved In Differentiation Heterotypic Cell-cell Adhesion	Extrinsic Apoptotic Signaling Pathway Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neuron Apoptotic Process Transmission Of Nerve Impulse Necroptotic Signaling Pathway Primary MiRNA Processing Neuron Death SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Communication Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Embryonic Foregut Morphogenesis Positive Regulation Of Endopeptidase Activity Lymphocyte Activation Foregut Morphogenesis Paraxial Mesoderm Development Positive Regulation Of Peptidase Activity Cell Differentiation Regulation Of Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Pericardium Development Apoptotic Process Leukocyte Activation Anatomical Structure Development Programmed Cell Death Regulation Of Myeloid Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Transport Protein Complex Assembly Cell Death Death Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Necroptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Regulation Of Cysteine-type Endopeptidase Activity Gene Silencing By MiRNA Membrane Depolarization During Action Potential
Tagcloud ?		adam19 atria conduction connexins coq7 cx40 dyrk1a electrocardiogram f5 gabpa hmgn1 lethality monosomic morc3 ms5yah natal ncx1 pde10a pinpoint precordial scn10a scn5a slc5a3 slc8a1 tfb1m tiam1 trisomic ts65dn ventricles	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Difference) ?		adam19 atria conduction connexins coq7 cx40 dyrk1a electrocardiogram f5 gabpa hmgn1 lethality monosomic morc3 ms5yah natal ncx1 pde10a pinpoint precordial scn10a scn5a slc5a3 slc8a1 tfb1m tiam1 trisomic ts65dn ventricles	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Intersection) ?