SCN1B and SCN2B

Number of citations of the paper that reports this interaction (PubMedID 6319405)
0

Data Source:
HPRD (in vivo)

		SCN1B	SCN2B
Description		sodium voltage-gated channel beta subunit 1	sodium voltage-gated channel beta subunit 2
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Intercalated Disc Membrane T-tubule Axon Node Of Ranvier Sodium Channel Complex Cell Projection Perikaryon	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane T-tubule Axon Node Of Ranvier Cell Projection Axon Initial Segment Synapse
	Molecular Function	Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Sodium Ion Transport Monoatomic Ion Transport Sodium Ion Transport Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Neuron Projection Development Sodium Ion Transmembrane Transport Locomotion Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Voltage-gated Sodium Channel Activity	Monoatomic Ion Transport Sodium Ion Transport Chemical Synaptic Transmission Nervous System Development Response To Heat Gene Expression Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Response To Pyrethroid Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Ranolazine Phenytoin Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil	Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Brugada syndrome (BRS)
GWAS		Metabolite levels ( 23823483) Serum albumin levels ( 23022100)	Preeclampsia ( 23551011)
Interacting Genes		6 interacting genes: ADRA1A ANK3 C5AR2 F2RL1 NFASC SCN2B	2 interacting genes: CFTR SCN1B
Entrez ID		6324	6327
HPRD ID		02581	03208
Ensembl ID		ENSG00000105711	ENSG00000149575
Uniprot IDs		A0A1W2PR05 Q07699	O60939 Q5U0K8
PDB IDs		6AGF 6J8G 6J8H 6J8I 6J8J 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8FHD 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8J4F 8S9B 8S9C 8THG 8THH 8XMM 8XMN 8XMO	5FDY 5FEB 6J8E 6J8G 6J8H 6J8I 6J8J 6VRR 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8S9B 8S9C 8THG 8THH 8XMN 8XMO
Enriched GO Terms of Interacting Partners?		Node Of Ranvier Axon Initial Segment Positive Regulation Of Cytosolic Calcium Ion Concentration Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport T-tubule Regulation Of Membrane Depolarization Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure G Protein-coupled Receptor Activity Regulation Of Membrane Potential Plasma Membrane Axon Basal Plasma Membrane Regulation Of Sodium Ion Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Response To Pyrethroid Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Biological Quality Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of System Process Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Action Potential Maintenance Of Protein Location In Plasma Membrane Proteinase-activated Receptor Activity Regulation Of Interleukin-8 Production Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Complement Component C5a Receptor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Interleukin-6 Production Positive Regulation Of Killing Of Cells Of Another Organism Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Complement Component C5a Signaling Pathway Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade	Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Ion Transport Corticospinal Neuron Axon Guidance Positive Regulation Of Anion Channel Activity Positive Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Anion Transport Regulation Of Voltage-gated Sodium Channel Activity Membrane Depolarization During Purkinje Myocyte Cell Action Potential Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Sodium Channel Inhibitor Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Channel Complex Amelogenesis Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Action Potential Propagation Neuronal Action Potential Propagation Voltage-gated Sodium Channel Complex Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Inorganic Ion Transmembrane Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Membrane Depolarization During Cardiac Muscle Cell Action Potential Monoatomic Ion Transmembrane Transport Response To Forskolin Positive Regulation Of Sodium Ion Transmembrane Transport Chloride Transmembrane Transporter Activity Sperm Capacitation Node Of Ranvier Positive Regulation Of Transport Membrane Depolarization During Action Potential
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