SCN1A and NAB2

		SCN1A	NAB2
Description		sodium voltage-gated channel alpha subunit 1	NGFI-A binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Plasma Membrane Intercalated Disc Membrane Nuclear Body Z Disc T-tubule Axon Node Of Ranvier Monoatomic Ion Channel Complex Sodium Channel Complex Neuronal Cell Body Axon Initial Segment	Nucleus Nucleoplasm
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Adult Walking Behavior Determination Of Adult Lifespan Neuronal Action Potential Propagation Neuronal Action Potential Nerve Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Controlling Posture Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Establishment Of Localization In Cell Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Regulation Of Presynaptic Membrane Potential	Endochondral Ossification Regulation Of DNA-templated Transcription Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Phenacemide Chloroprocaine Phenazopyridine Nitrazepam Permethrin Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Familial or sporadic hemiplegic migraine Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
GWAS		Epilepsy ( 25087078 30531953) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 22949513 30531953) Mesial temporal lobe epilepsy with hippocampal sclerosis ( 24014518) Whole brain grey matter density ( 31530798)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 29273806 31361310 31619474 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)
Interacting Genes		5 interacting genes: CALM1 NEDD4 PSEN1 SNTA1 YAP1	80 interacting genes: ANK3 ANKRD11 CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM200C FAM9A GCC1 GOLGA6L9 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RFC5 RINT1 SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZMAT2 ZMYND12 ZMYND19 ZNF417
Entrez ID		6323	4665
HPRD ID		01669	03854
Ensembl ID		ENSG00000144285	ENSG00000166886
Uniprot IDs		A0A286YF26 P35498	Q15742
PDB IDs		7DTD
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Transmembrane Transporter Binding Proline-rich Region Binding Protein-containing Complex Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Tube Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Mesenchyme Development Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Sodium Ion Transport Formation Of Structure Involved In A Symbiotic Process Neuromuscular Junction Negative Regulation Of Core Promoter Binding PDZ Domain Binding ATPase Binding Embryonic Heart Tube Morphogenesis Enterocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Negative Regulation Of Transmembrane Transport Negative Regulation Of RNA Metabolic Process Channel Inhibitor Activity Sarcolemma Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Tube Morphogenesis Cajal-Retzius Cell Differentiation Regulation Of Nucleocytoplasmic Transport Transcription Coregulator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Import Into Cell Regulation Of Transport Response To Calcium Ion Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Transport Phosphothreonine Residue Binding Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding TEAD-YAP Complex Regulation Of Cell Projection Organization Negative Regulation Of Transcription By RNA Polymerase III Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
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