RPS14 and PEX6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RPS14	PEX6
Gene Name		ribosomal protein S14	peroxisomal biogenesis factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding Translation Regulator Activity MRNA 5'-UTR Binding	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Complex Binding ATPase Activity, Coupled
	Biological Process	Ribosomal Small Subunit Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination Regulation Of Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Erythrocyte Differentiation Maturation Of SSU-rRNA Cellular Protein Metabolic Process	Protein Targeting To Peroxisome Peroxisome Organization Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Stabilization
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		8 interactors: APP CALM1 PEX6 RBBP6 RLIM SMAD2 TAF9 TMEM33	7 interactors: ATF7IP CERS2 PEX1 PEX26 RPL27A RPS14 SMAD3
Entrez ID		6208	5190
HPRD ID		00562	03293
Ensembl ID		ENSG00000164587	ENSG00000124587
Uniprot IDs		P62263	Q13608 Q8WYQ1
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Random Inactivation Of X Chromosome Protein Stabilization Growth Secretion By Cell Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Synaptic Growth At Neuromuscular Junction Regulation Of Protein Stability Secretion Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Protein Import Into Peroxisome Matrix, Translocation Collateral Sprouting In Absence Of Injury Zygotic Specification Of Dorsal/ventral Axis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Transcription Initiation From RNA Polymerase II Promoter Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity Cellular Protein Modification Process Platelet Activation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesoderm Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Primary MiRNA Processing Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Nodal Signaling Pathway Axon Choice Point Recognition Common-partner SMAD Protein Phosphorylation DNA-templated Transcription, Initiation Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Neuron Remodeling Regulation Of Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Developmental Growth Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Transcription From RNA Polymerase II Promoter Detection Of Calcium Ion SMAD Protein Complex Assembly Regulation Of Cell Communication By Electrical Coupling Dosage Compensation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phosphoprotein Phosphatase Activity	Establishment Of Protein Localization To Organelle Protein Targeting Protein Import Into Peroxisome Matrix Protein Localization To Organelle Viral Process Protein Targeting To Membrane Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Cytoplasmic Transport Establishment Of Protein Localization To Membrane Intracellular Protein Transport Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Localization To Membrane Protein Transmembrane Transport Viral Transcription Positive Regulation Of Transforming Growth Factor Beta3 Production Cellular Protein Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Protein Transport Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Intracellular Transport Protein Localization To Endoplasmic Reticulum Microtubule-based Peroxisome Localization Translational Termination Nuclear-transcribed MRNA Catabolic Process Evasion Or Tolerance Of Host Defenses By Virus Protein Import MRNA Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Translational Elongation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly RNA Catabolic Process Protein Localization Cellular Protein Complex Disassembly Viral Life Cycle Regulation Of Extracellular Matrix Assembly Establishment Of Localization In Cell Membrane Organization Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Protein Import Into Peroxisome Membrane Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Peroxisomal Membrane Transport
Tagcloud ?		aquaticus eubacteria identities intergenic l14 l15 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rpl15 rps17 rps8 s10 s17 spacer spc thermophile thermophilus thermotoga thermus	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Difference) ?		aquaticus eubacteria identities intergenic l14 l15 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rpl15 rps17 rps8 s10 s17 spacer spc thermophile thermophilus thermotoga thermus	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Intersection) ?