RPL9 and BACH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPL9	BACH2
Description		ribosomal protein L9	BACH transcriptional regulator 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cytoplasmic Translation Translation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Type I diabetes mellitus
GWAS		Alcohol consumption (drinks per week) ( 30643258)	Addison's disease ( 33574239) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 29273806 34103634 32296059 31959851 31619474 31361310 30929738 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Basophil count ( 32888494) Celiac disease ( 30572963 20190752 24999842 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 22922229 21841780) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 27992413 23603763) Red blood cell count ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 30572963 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962 23273568 27399966) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 19430480 18978792 21829393 30572963 18840781 25751624) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)
Interacting Genes		39 interacting genes: BACH2 BICDL2 CALCOCO2 CBY2 CCDC184 CEBPA CEP76 CTTN DHPS DRAP1 DUX4 ESR1 FAM9B HMBOX1 HOMEZ KXD1 MOCS2 MTUS2 OGT PNMA2 PPP1R27 PSTPIP1 QKI RALY RPS3 SNRPF SORBS2 SREK1IP1 SRSF3 STAC3 SUPT5H TIFA TNFAIP8L1 TRIM37 UBALD1 USO1 ZBTB14 ZBTB7B ZBTB8A	45 interacting genes: ANKRD55 AP1M1 BAHD1 BATF3 CBX8 CCDC185 CENPP CFAP58 CTSZ CWF19L2 DDIT3 ELOA ENPP7 FAM161A FARS2 FOSL2 FUS HMG20A INSYN2A KAT5 LUZP4 MAFF MAFK MCRS1 MLX NFE2L1 NFE2L3 NXF1 PATZ1 PSMC5 RPL9 RPP25 SCNM1 SLC43A1 SMYD1 TCEA2 TRAF4 TRIM42 TSHZ2 TULP3 ZBTB24 ZNF124 ZNF438 ZNF774 ZNF792
Entrez ID		6133	60468
HPRD ID		04732	12012
Ensembl ID		ENSG00000163682	ENSG00000112182
Uniprot IDs		P32969 Q53Z07	Q9BYV9
PDB IDs		2CQL 4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	3OHU 3OHV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Integrated Stress Response Signaling Chromatin Binding Positive Regulation Of DNA Repair Regulation Of Myoblast Differentiation
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